Ekspresi mRNA Matrik Metalloproteinase-7 (MMP-7) dan Tissue Inhibitor of Metalloproteinase-1 (TIMP-1) pada Endometrium Perempuan Obesitas dengan Infertilitas (Expression of mRNA Matrix Metalloproteinase-7 (MMP-7) and Tissue Inhibitor of Metalloproteinase-1 (TIMP-1) in the Endometrium of Obese Women with Infertility)

Adelina Amelia Febriani Bofe, Dr. dr. Shofwal Widad, Sp.O.G, Subsp.F.E.R; dr. Dwi Aris Agung Nugrahaningsih, M.Sc, PhD

2024 | Tesis-Subspesialis | SUBSPESIALIS OBSTETRI DAN GINEKOLOGI

Obesitas menyebabkan perubahan pada endometrium yang diyakini menyebabkan perubahan pada protein dan ekspresi gen di endometrium yaitu MMP dan inhibitor alaminya, TIMP. MMP dan TIMP memainkan peran penting dalam remodeling jaringan endometrium. Terdapat 23 jenis MMP, terkhusus MMP-7 yang berperan dalam mendegradasi membarana basalis dan dalam proses apoptosis sedang TIMP-1 adalah inhibitornya. Pada perempuan obesitas terjadi proliferasi endometrium berlebih dan apoptosis jaringan yang terhambat sehingga menyebabkan infertilitas oleh karena penurunan reseptivitas endometrium, hal ini terdapat peran MMP-7 dan TIMP-1 didalamnya. 

Obesity causes changes in the endometrium, which is believed to result in alterations in protein and gene expression, specifically MMP and its natural inhibitor, TIMP. MMP and TIMP play a crucial role in endometrial tissue remodelling. There are 23 types of MMPs, specifically MMP-7, which is involved in degrading the basal membrane and apoptosis processes, while TIMP-1 acts as its inhibitor. In obese women, excessive endometrial proliferation and inhibited tissue apoptosis lead to infertility due to decreased endometrial receptivity. MMP-7 and TIMP-1 play a role in this process.

Kata Kunci : Matrix Metalloproteinase-7 (MMP-7), Tissue Inhibitor of Metalloproteinase-1 (TIMP-1), endometrium fase proliferasi, obesitas