Leukoaraiosis sebagai Prediktor Perburukan Fungsi Kognitif pada Pasien Demensia Vaskular di RSUP DR SARDJITO
Mutiah Muftihaturrahmah, dr. Amelia Nur Vidyanti, Ph.D, Sp.N, Subsp.NGD (K) ; dr. Subagya, Sp.N, Subsp.NGD (K)
2024 | Tesis-Spesialis | S2 Ilmu Penyakit Saraf
Latar belakang: Prevalensi Demensia Vaskular terus meningkat dengan hasil MRI kepala
banyak ditemukan Leukoaraiosis. Pemeriksaan
total tau dan beta amiloid dari cairan serebrospinal merupakan biomarker
perburukan fungsi kognitif, namun biayanya mahal, invasif dan membutuhkan rawat
inap. Leukoaraiosis diduga memiliki efek terhadap gangguan kognitif walaupun
hubungan antara keduanya masih kontroversi.
Metode: Penelitian kohort retrospektif dengan pengambilan
data rekam medis pasien yang terdiagnosis Demensia Vaskular dari poli memori
RSUP Dr. Sardjito tahun 2018 sampai 2023. Tujuan penelitian ini adalah untuk
mengetahui hubungan derajat leukoaraiosis terhadap fungsi kognitif pada pasien
Demensia Vaskular. Terdapat 65 subjek yang memenuhi kriteria inklusi dan
eksklusi. Pemeriksaan fungsi kognitif dilakukan saat awal dan kontrol
berikutnya setelah dilakukan pemeriksaan MRI kepala. Analisis data dilakukan menggunakan uji
statistik deskriptif dan regresi linier berganda dengan spss versi 27.
Hasil: Rerata usia subjek adalah 67.62±10.11 tahun. Hasil MRI kepala didominasi Leukoaraiosis fazekas 1 (43.08%) dengan rerata durasi follow-up 14.18±9.27 bulan. Hasil analisis multivariat derajat Leukoaraiosis berpengaruh signifikan terhadap ?MoCA-INA (p < 0>
Kesimpulan: Hasil
studi ini menunjukkan bahwa terdapat hubungan antara derajat Leukoaraiosis
dengan penurunan fungsi kognitif pada pasien Demensia Vaskular di RSUP Dr
Sardjito Yogyakarta.
Background: The prevalence of Vascular Dementia increased
and most of patients were found Leukoaraiosis in MRI. Cerebrospinal fluid total
tau and amyloid beta are used as biomarker of cognitive decline but they are
expensive, invasive and requires hospitalization. Leukoaraiosis is suspected to
have an effect on cognitive decline, although their association remains
controversial.
Method: A retrospective cohort study was conducted
using medical records of patients diagnosed with Vascular Dementia from the
memory clinic at Dr. Sardjito General Hospital from 2018 until 2023. The aim of
this study is to determine the association between Leukoaraiosis and cognitive decline
in Vascular Dementia. A total of 65 subjects met the inclusion and exclusion
criteria. Cognitive function assessments were performed at the initial visit
and at the next follow-up after brain MRI examinations. Data analysis was
conducted using descriptive statistics and multiple linear regression tests
with SPSS version 27.
Results: The mean age of the subjects was 67.62±10.11 years. Brain MRI results were predominantly Leukoaraiosis Fazekas grade 1 (43.08%), with an average follow-up duration of 14.18±9.27 months. Multivariate analysis showed that the degree of Leukoaraiosis had a significant effect on ?MoCA-INA (p < 0>
Conclusion: The
results of this study indicate that there is an association between Leukoaraiosis
and cognitive decline in Vascular Dementia patients at Dr. Sardjito General
Hospital, Yogyakarta.
Kata Kunci : demensia vaskular, leukoaraiosis, perburukan fungsi kognitif