Perbandingan Efek Kardiotoksisitas Trastuzumab Dengan Antrasiklin Yang Diikuti Trastuzumab Pada Pasien Kanker Payudara
Laras Ratna Sari, drh. Retno Murwanti, M.P. Ph.D ; Dr. apt. Fita Rahmawati, Sp.FRS
2024 | Tesis | S2 Mag.Farmasi Klinik
Breast cancer is a cancer that has the largest incidence in women in Indonesia. Currently, there are various therapies for breast cancer, including chemotherapy and immunotherapy (trastuzumab). The use of chemotherapy and immunotherapy has proven to be effective as therapy for breast cancer, but both have cardiotoxic effects. This study aims to compare the incidence of early cardiotoxicity using trastuzumab and an anthracycline regimen followed by trastuzumab in breast cancer patients at RSUP Dr. Sardjito.
The research design used was a retrospective cohort and data collection was carried out based on outpatient medical records in the period January 2018 – December 2023. The sampling technique used consecutive sampling. A total of 51 patient medical records met the inclusion criteria, namely 33 patients in the group who received trastuzumab therapy and 18 patients in the group who received an anthracycline regimen followed by trastuzumab. The data obtained will be analyzed statistically using bivariate analysis, independent t test to determine the effect of cardiotoxicity and multivariate logistic regression analysis.
The results of this study were based on the mean Left Ventricular Ejection Fraction (LVEF) value, there was no significant difference (p>0.05) between the trastuzumab and anthracycline groups followed by trastuzumab and none of the patients had an LVEF value <50 p=0.002)> 10% with the largest decrease being 27.7% and in the anthracycline group followed by trastuzumab there were 10 patients out of 18 patients (55.6%) who experienced a decrease in LVEF > 10% with the largest decrease being 22%. Additional data are needed to obtain results that better describe cardiotoxicity in the two groups.
Kata Kunci : efek kardiotoksisitas, trastuzumab,antrasiklin, kanker payudara