Efek Fotoprotektif Serisin Samia ricini (Drury, 1773) terhadap Viabilitas dan Produksi Kolagen pada Sel Human Dermal Fibroblast yang Diiradiasi Sinar UVB
CINTYA ANGELINA, Dr. Slamet Widiyanto, S.Si., M.Sc.; Dr. Ardaning Nuriliani. S.Si., M.Kes.
2024 | Skripsi | BIOLOGI
Serisin
merupakan polimer protein alami dari kokon ulat sutera. Serisin
diketahui memiliki berbagai aktivitas biologis seperti efek antioksidan,
ultraviolet (UV) protektan dan anti penuaan. Radiasi UVB (290–320 nm) pada sel
kulit dapat memicu stres oksidatif yang mengakibatkan menurunnya viabilitas sel
dan degradasi kolagen. Aktivitas perlindungan ekstrak serisin Samia
ricini terhadap kerusakan kulit akibat sinar UVB masih belum banyak
dieksplorasi di Indonesia. Penelitian ini bertujuan untuk mempelajari potensi
ekstrak serisin kokon ulat sutera Samia ricini sebagai UV protektan sel Human
Dermal Fibroblast karena paparan sinar UVB dengan mengetahui aktivitas
viabilitas sel dan produksi kolagen. Serisin diuji in vitro terhadap sel
HDF pada 2 jenis kerapatan sel (5x103 dan 104/sumuran) yang diiradiasi
sinar UVB (280
mJ/<!--[if gte msEquation 12]>
Sericin is a natural protein polymer from silkworm cocoons. Sericin is
known to have various biological activities such as antioxidant, ultraviolet
(UV) protective and anti-aging effects. UVB radiation (290–320 nm) on skin
cells can trigger oxidative stress which results in decreased cell viability
and collagen degradation. The protective activity of Samia ricini
sericin extract against skin damage caused by UVB rays has not yet been widely
explored in Indonesia. This research aims to study the potential of sericin as
a UV protectant for Human Dermal Fibroblast cells due to exposure to UVB light
by determining cell viability activity and collagen production. Sericin was
tested in vitro against HDF cells at 2 types of cell density (5x103 dan
104 cells/well)
irradiated with UVB light (280 mJ/<!--[if gte msEquation 12]>
Kata Kunci : Sel HDF (Human Dermal Fibroblast), photoaging, sinar UVB, kokon ulat sutera, serisin