Association between C-reactive protein (CRP) and blood glucose plasma level in severe to critical COVID-19 patients at dr. Sardjito General Hospital, Yogyakarta

SITI AZIZA ROZA PUTRI, dr. Hemi Sinorita, SpPD-KEMD; dr. Heni Retno Wulan, M.Kes., Sp.PD-KP

2023 | Skripsi | PENDIDIKAN DOKTER

Selama pandemi COVID-19, penelitian secara konsisten telah menunjukkan bahwa individu dengan kadar glukosa plasma yang tinggi cenderung memiliki prognosis yang lebih buruk karena adanya infeksi SARS-CoV-2 dan hiperglikemia yang memicu inflamasi sistemik. Untuk menyelidiki hubungan antara kadar glukosa dan respons inflamasi yang berkontribusi terhadap memburuknya infeksi COVID-19, C-reactive protein (CRP), salah satu marker inflamasi, telah digunakan dalam berbagai penelitian. Tujuan penelitian ini adalah untuk mengkaji hubungan kadar glukosa plasma dengan CRP pada pasien COVID-19 parah hingga kritis yang dirawat di RSUP dr.Sardjito Yogyakarta.

Studi data sekunder yang dilaksanakan pada pasien COVID-19 parah hingga kritis didapatkan dari RSUP dr.Sardjito. Mereka yang dirawat di rumah sakit dan menderita diabetes mellitus sebagai morbiditas juga disertakan. Dalam studi cross-sectional retrospektif ini, hubungan pasien COVID-19 yang parah hingga kritis, status inflamasi (khususnya CRP), dan hiperglikemia dianalisis. Tingkat keparahan pasien COVID-19 ditentukan berdasarkan pedoman yang dikeluarkan oleh National Institute of Health (NIH). C-reactive protein (CRP) berfungsi sebagai variabel terikat, sedangkan glukosa plasma acak saat masuk berfungsi sebagai variabel bebas. Distribusi dan frekuensi dianalisis secara statistik sebagai variabel perancu. Selanjutnya, dilakukan analisis bivariat Pearson correlation untuk menilai kekuatan hubungan antara hiperglikemia saat masuk rumah sakit dengan CRP dan uji regresi linier multipel dilakukan untuk memperkirakan dampak hiperglikemia saat masuk rumah sakit dan faktor lain terhadap CRP.

During the COVID-19 pandemic, research has consistently shown that individuals with elevated glucose plasma levels tend to have a poorer prognosis, as both SARS-CoV-2 infection and hyperglycemia trigger systemic inflammation. To investigate the relationship between glucose levels and inflammatory response, which contributes to the worsening of COVID-19 infection, C-reactive protein (CRP), one of the well-established markers of inflammation, has been employed in various studies. The purpose of this research is to assess the association between blood glucose plasma levels and CRP in severe to critical COVID-19 patients admitted at dr. Sardjito General Hospital, Yogyakarta.

A secondary data study done among severe to critical COVID-19 patients from dr. Sardjito General Hospital is obtained. Those hospitalized and with diabetes mellitus as a morbidity is included. In this retrospective cross-sectional study, the relationship of severe to critical COVID-19 patients, inflammatory status (specifically CRP), and hyperglycemia are analyzed. Severity of COVID-19 patients were determined according to National Institute of Health (NIH) issued guidelines. C-reactive protein (CRP) serves as the dependent variable while random plasma glucose at admission serves as the independent variable. Distribution and frequency are statistically analyzed as confounding variables. Furthermore, bivariate Pearson correlation analysis is conducted to assess the strength of the relationship between hyperglycemia on admission and CRP and multiple linear regression test is conducted to estimate the impact of hyperglycemia on admission and other factors against CRP.

Kata Kunci : hyperglycemia, C-reactive protein, COVID-19, blood glucose, association