Hubungan Antara Faktor Klinikohistopatologi dan Kualitas Hidup Pasien Kanker Ovarium Pasca Operasi Di RSUP Dr. Sardjito Yogyakarta Menggunakan Model Kuesioner EORTC QLQ-C30

Arif Tantri Hartoyo, Dr. dr. Addin Trirahmanto, Sp.O.G, Subsp. Onk; Dr. dr. Ardhanu Kusumanto, Sp.O.G. Subsp.Onk

2024 | Tesis-Spesialis | S2 Ilmu Kebidanan dan Penyakit Kandungan

Latar Belakang: Kanker ovarium memiliki prognosis terburuk dan tingkat kematian tertinggi. Prognosis berkaitan dengan kualitas hidup pada pasien. Prognosis yang baik umumnya akan berdampak pada kualitas hidup yang baik pula. Data klinis pasien dan jenis histopatologi kanker ovarium berdampak pada kualitas hidup pasien sehingga mempengaruhi prognosis. Penelitian ini bertujuan untuk mengetahui hubungan antara faktor klinikohistopatologi dan kualitas hidup pasien kanker ovarium pasca operasi di RSUP Dr. Sardjito Yogyakarta.

Metode: Penelitian ini merupakan penelitian analisis hubungan dengan rancangan studi prospektif pada penderita kanker ovarium di RSUP Dr. Sardjito. Subjek adalah semua pasien kanker ovarium yang yang menjalani operasi primer pada Agustus 2022 – Agustus 2023 di RSUP Dr. Sardjito. Data subjek yang memenuhi kriteria inklusi kemudian akan dikumpulkan dan dilakukan pengolahan data.

Hasil : Berdasarkan data yang diperoleh terdapat total 43 sampel kanker ovarium yang menjalani pembedahan (operasi) primer di RSUP Dr. Sardjito. Didapatkan kualitas hidup Sebagian besar dalam kategori kualitas hidup tinggi sebanyak 25 pasien (58,14%) dengan rata-rata skor kualitas hidup 86.33 dan sisanya kategori kualitas hidup rendah sebanyak 18 pasien (41,86%) dengan rata-rata skor kualitas hidup 53,41. didapatkan faktor kliniko histopatologi (stadium dan residu tumor) ada hubungan bermakna secara statistik terhadap kualitas hidup pasien kanker ovarium pasca operasi di RSUP Dr. Sardjito dengan hasil masing-masing faktor stadium p=0,001 (RR 3,375 , IK 95% 1,578 – 7,219), faktor residual tumor p=0,031 (RR 2,327, IK 95% 1,241 – 4,363).

Kesimpulan : Terdapat hubungan antara faktor klinikohistopatologi (stadium tumor dan residu tumor) dengan kualitas hidup pasien kanker ovarium pasca operasi di RSUP Dr. Sardjito Yogyakarta secara statistik uji bivariat memiliki hubungan signifikan secara klinis.

Background: Ovarian cancer has the worst prognosis and the highest mortality rate. Prognosis is related to the patient's quality of life. A good prognosis will generally have an impact on a good quality of life. The patient's clinical data and histopathological type of ovarian cancer have an impact on the patient's quality of life, thereby influencing the prognosis. This study aims to determine the relationship between clinico histopathological factors and the quality of life of post-operative ovarian cancer patients at RSUP Dr. Sardjito Yogyakarta

 

Method: This research is a relationship analysis study with a prospective study design in ovarian cancer sufferers at RSUP Dr. Sardjito. Subjects were all ovarian cancer patients who underwent primary surgery in August 2022 – August 2023 at RSUP Dr. Sardjito. Subject data that meets the inclusion criteria will then be collected and data processing will be carried out.

 

Results: Based on the data obtained, there were a total of 43 ovarian cancer samples that underwent primary surgery at Dr. RSUP. Sardjito. The quality of life was found to be mostly in the high quality of life category, 25 patients (58.14%) with an average quality of life score of  86.33 and the remaining 18 patients in the low quality of life category (41.86%) with an average quality of life score of 53.41. It was found that clinico histopathological factors (stage and tumor residue) had a statistically significant relationship with the quality of life of post-operative ovarian cancer patients at Dr. Sardjito with the results of each stage factor being p=0.001 (RR 3.375, 95% CI 1.578 – 7.219), residual tumor factor p=0.031 (RR 2.327, 95% CI 1.241 – 4.363).

 

Conclusion: There is a relationship between clinicohistopathological factors (tumor stage and tumor residue) and the quality of life of post-operative ovarian cancer patients at RSUP Dr. Sardjito Yogyakarta, statistically the bivariate test has a clinically significant relationship.

Kata Kunci : Kualitas hidup, Klinikohistopatologi, Kanker Ovarium, Kuesioner EORTC QLQ-C30, Quality of life, Clinical Histopathology, Ovarian Cancer, EORTC QLQ-C30 Questionnaire