HUBUNGAN ANTARA RADIOLOGICFEATURE, LOKASI DAN LATERALISASI MENINGIOMA PADAPEMERIKSAAN MRI KEPALA DENGAN EKSPRESI Ki-67

SITI MARYAM, Dr. dr. Lina Choridah, Sp.Rad(K)-PRP; dr. Hesti Gunarti, Sp.Rad(K)-RA

2024 | Tesis | S2 Kedokteran Klinik

Latar Belakang: Meningioma adalah tumor intrakranial primer yang paling umum

dengan insiden 2,3 – 8,3 per 100.000 orang. Indeks Ki-67 menjadi faktor yang

konsisten untuk membedakan meningioma anaplastik dan jinak. Temuan Radiologic

feature, lokasi, lateralisasi meningioma pada pemeriksaan MRI kepala berguna dalam

memprediksi Ki-67 pada pasien meningioma untuk menentukan prognosis dan terapi.

Tujuan: Penelitian ini bertujuan mengetahui hubungan antara radiologic feature,

lokasi dan lateralisasi Meningioma pada pemeriksaan MRI kepala dengan ekspresi Ki-

67.

Metode: Penelitian dengan desain cross sectional ini dilakukan di RSUP Dr Sardjito

Yogyakarta dengan mengambil data sekunder dari pasien yang melakukan

pemeriksaan MRI kepala dan patologi anatomik dengan hasil Meningioma di RS

Sardjito Yogyakarta periode Januari 2019-November 2023. Subjek diambil

menggunakan purposive sampling. Foto MRI kepala dan hasil Ki-67 dari 29 subjek

yang memenuhi kriteria inklusi diambil untuk dianalisis. Data diambil dari PACS dan

rekam medis.

Hasil: Mayoritas sampel berjenis kelamin perempuan (82,8%) dan rerata berusia 51,1

tahun. Lokasi meningioma terbanyak di Convexity (69,0). Lateralisasi didapatkan pada

22 pasien (75.9%). Derajat histopalogi menurut grading WHO terbanyak grade

1(44.8%). Terdapat hubungan yang signifikan ukuran tumor pada Radiologic features

dengan Ki 67 (p=0,014, r=0,450). Didapatkan Hubungan yang signifikan antara

lateralisasi dengan Ki 67 (p=0,046; r=0,373). Tidak ditemukan hubungan yang

signifikan antara lokasi Meningioma dengan Ki 67 (p=0,989; r=0,003).

Kesimpulan: Terdapat hubungan yang signifikan ukuran tumor pada Radiologic features

dengan Ki 67. Terdapat hubungan yang signifikan antara lateralisasi dengan ki 67. Tidak

ditemukan hubungan yang signifikan antara lokasi Meningioma dengan Ki 67

(p=0,989; r=0,003).

Kata Kunci: Meningioma, Ki-67,radiologic feature, lokasi, lateralisasi.

Background: Meningioma is the most common primary intracranial tumor with an

incidence of 2.3 – 8.3 per 100,000 people. The Ki-67 index is a consistent factor for

differentiating anaplastic and benign meningiomas. Radiologic feature findings,

location, lateralization of meningioma on MRI of the head are useful in predicting

Ki-67 in meningioma patients to determine prognosis and therapy.

Objective: This study aims to determine the relationship between radiological

features, location and lateralization of meningioma on head MRI examination with

Ki-67 expression.

Method: This research with a cross sectional design was carried out at Dr Sardjito

Hospital Yogyakarta by taking secondary data from patients who underwent head

MRI and anatomical pathology examinations with Meningioma results at Sardjito

Hospital Yogyakarta for the period January 2019-November 2023. Subjects were

taken using purposive sampling. Head MRI photographs and Ki-67 results from 29

subjects who met the inclusion criteria were taken for analysis. Data were taken from

PACS and medical records.

Results: The majority of the sample was female (82.8%) and the average age was

51.1 years. The most common meningioma locations were in Convexity (69.0).

Lateralization was found in 22 patients (75.9%). The highest degree of histopology

according to WHO grading was grade 1 (44.8%). There is a significant relationship

between tumor size and radiologic features with Ki 67 (p=0.014, r=0.450). A

significant relationship was found between lateralization and Ki 67 (p=0.046;

r=0.373). No significant relationship was found between Meningioma location and

Ki 67 (p=0.989; r=0.003).

Conclusion: There is a significant relationship between tumor size and radiologic

features with Ki 67. There is a significant relationship between lateralization and Ki

67. There was no significant relationship between the location of the meningioma

and Ki 67 (p=0.989; r=0.003).

Keywords: Meningioma, Ki-67, radiological features, location, lateralization.

Kata Kunci : Meningioma, Ki-67,radiologic feature, lokasi, lateralisasi.