Latar Belakang: Metastasis otak merupakan neoplasma intrakranial terbanyak pada populasi dewasa, dengan kejadian > 50%ri keseluruhan kasus tumor intrakranial. Tatalaksana metastasis otak, baik monoterapi maupun kombinasi, terus mengalami perkembangan untuk memperpanjang kesintasan dan luaran penderita. Penelitian ini bertujuan untuk membandingkan antara status fungsional pasien yang menerima monoterapi dengan terapi kombinasi dengan menggunakan skor Karnofsky Performance Scale (KPS)
Metode: Penelitian ini merupakan studi kohort retrospektif yang melibatkan 124 pasien metastasis otak RSUP Dr Sardjito di Yogyakarta. Data diperoleh melalui cancer registry neuro-onkologi pasien metastasis otak yang memenuhi kriteria inklusi. Analisis data dilakukan dengan tiga tahapan, yaitu analisis univariat, bivariat, dan multivariat. Nilai p<0 xss=removed p=0,013), p=0,039), p=0,001; p=0,001;>
Kesimpulan: Terdapat perbedaan signifikan antara monoterapi dibandingkan dengan terapi kombinasi dengan skor KPS lebih tinggi pada pasien yang menerima terapi kombinasi.
Background: Brain metastases (BM) are the most common intracranial neoplasms in the adult population, with an incidence of > 50% of all cases of intracranial tumors. Management of BM continues to develop to increase patient survivability. This study aimed to compare the functional status of patients who receive monotherapy with combination therapy by using the Karnofsky Performance Scale (KPS) score.
Methods: This research is a retrospective cohort study involving 124 brain metastasis patients from RSUP Dr. Sardjito in Yogyakarta. Data was obtained through cancer registry neuro-oncology of BM patients who met the inclusion criteria. Data analysis was carried out in three stages, namely univariate, bivariate, and multivariate. The p-value <0>
Results: The average age of patients with brain metastases was 55.13 years, with a predominance of females (64.8%). The majority of patients had no comorbidities (74.2%), the source of the primary tumor was breast cancer (37.9%), had a tumor size < 3 xss=removed p=0.013), p=0.039), p=0.001; p=0.001;>
Conclusion: There is a significant difference between monotherapy compared with combination therapy with higher KPS scores in patients receiving combination therapy.
Kata Kunci : brain metastases, combination therapy, functional status, monotherapy
