Risiko Keparahan COVID-19 Berdasarkan Cycle Threshold Value SARS-CoV-2

Tri Lestari, Dr. dr. Umi S. Intansari, M.Kes, Sp.PK(K) ; dr. Windarwati, M.Sc, Sp.PK(K)

2024 | Tesis-Spesialis | S2 Ilmu Patologi Klinik

Pandemi COVID-19 menyebabkan tingginya angka morbiditas dan mortalitas. Infeksi SARS-CoV-2 menyebabkan berbagai gejala mulai asimptomatik, gejala ringan hingga berat yang berkembang menjadi gagal nafas dan berakhir dengan kematian. Pengujian sampel yang cepat dan akurat sangat diperlukan dalam menentukan diagnosis serta tatalaksana pasien COVID-19. Real time reverse transcription polymerase chain reaction merupakan standar emas untuk mendeteksi SARS-CoV-2 dengan indikator kepositifannya yaitu CT-value. Hasil penelitian CT-value dengan derajat keparahan COVID-19 belum banyak dan hubungannya dengan derajat keparahan masih kontradiktif.

The COVID-19 pandemic has led to high morbidity and mortality rates. SARS-CoV-2 infection causes a variety of symptoms ranging from asymptomatic, mild to severe symptoms that progress to respiratory failure and end in death. Rapid and accurate sample testing is essential in determining the diagnosis and management of COVID-19 patients. Real time reverse transcription polymerase chain reaction is the gold standard for detecting SARS-CoV-2 with the indicator of positivity being CT-value. The results of CT-value research with COVID-19 severity have not been much and its relationship with severity is still contradictory.

Kata Kunci : COVID-19, RT-PCR, CT-value, viral load, derajat keparahan