Neutrophil To Lymphocyte Ratio (NLR), Platelet To Lymphocyte Ratio (PLR), dan Eosinopenia Sebagai Prediktor Luaran Pasien Pediatric Acute Respiratory Distress Syndrome (PARDS)

Garida Zuarisa, Dr. Med. dr. Intan Fatah Kumara, M.Sc, Sp.A(K) dan dr. Dwikisworo Setyowireni, Sp.A(K)

2023 | Tesis | S2 Kedokteran Klinik

Latar belakang: Pediatric Acute Respiratory Distres Syndrome (PARDS) merupakan kondisi dengan dasar inflamasi yang memiliki mortalitas dan morbiditas tinggi di negara berkembang. Diperlukan prediktor untuk memprediksi luaran PARDS berupa mortalitas dan pemanjangan durasi ventilasi mekanik yang murah dan bisa diakses disemua fasilitas kesehatan terutama di fasilitas kesehatan perifer. Neutrophil to Lymphocyte Ratio (NLR), Platelet to Lymphocyte Ratio (PLR) dan eosinopenia diketahui menjadi biomarker pada beberapa kondisi inflamasi. Tujuan: Mengetahui peran NLR, PLR dan eosinopenia sebagai prediktor luaran PARDS. Metode: Penelitian dilakukan secara kohort retrospektif pada pasien PARDS yang dirawat di PICU RSUP Dr. Sardjito Yogyakarta pada Januari 2017–Desember 2022. Sampel diambil secara consecutive sampling dengan kriteria inklusi dan eksklusi. Analisis dilakukan menggunakan analisis bivariat dengan uji Chi square (X2) atau uji Fisher  s exact dan multivariat regresi logistik. Hasil antara variabel dinyatakan dengan odd ratio (OR) dan interval kepercayaan 95?ngan tingkat kemaknaan statistik p<0 p=0,034) p=0,029)>

Background: Pediatric Acute Respiratory Distres Syndrome (PARDS) is an inflammatory based condition that continues to be a significant problem with high mortality and morbidity rates in developing countries. Predictors are needed to forecast outcomes of PARDS, such as mortality and prolonged mechanical ventilation duration, which are cost-effective, routinely performed, and accessible in all healthcare facilities, especially in peripheral healthcare facilities. Neutrophil to Lymphocyte Ratio (NLR), Platelet to Lymphocyte Ratio (PLR) are known to be biomarkers in some inflammatory diseases. Objective: To determine the role of NLR, PLR, and eosinopenia as predictors of PARDS outcomes. Methods: A retrospective cohort study was conducted on PARDS patients treated in the PICU of Dr. Sardjito Hospital in Yogyakarta from January 2017 to December 2022. Samples were collected using concecutive sampling with inclusion and exclusion criteria. The analysis was performed using bivariate analysis with the Chi-square (X2) test or Fisher  s exact test and multivariate logistic regression. Results between variables were expressed as odds ratios (OR) with a 95% confidence interval, with a statistical significance level of p<0 p=0.034) p=0.029)>

Kata Kunci : PARDS, mortalitas, ventilasi mekanik, NLR, PLR, eosinopenia, mortality, mechanical ventilation, NLR, PLR, eosinopenia