Korelasi Gambaran Radiologi Computed Tomography Karsinoma Hepatoseluler Berdasarkan Barcelona Clinic Liver Cancer Dengan Skor ALBI (Albumin - Bilirubin)

Jimmy Indarto Gunawan, Dr. dr. Bagaswoto Poedjomartono, Sp.Rad (K) RI, Sp.KN, M.Kes, FICA.; dr. Wigati Dhamiyati, Sp.Rad (K) Onk Rad

2023 | Tesis | S2 Kedokteran Klinik

Latar Belakang : Hepatoseluler karsinoma menempati peringkat kelima penyebab kematian akibat tumor ganas di asia. Persentase kemampuan bertahan hidup dalam 5 tahun hepatoseluler karsinoma sebesar 18% menjadikannya tumor paling mematikan nomor dua. Skor ALBI menjadi salah satu faktor penentu dari prognosis hepatoseluler karsinoma.Tujuan : Tujuan penelitian ini adalah untuk membuktikan adanya korelasi antara skor ALBI dengan gambaran radiologi CT hepatoseluler karsinoma berdasarkan BCLC pada pasien hepatoseluler karsinoma. Bahan dan Metode : Penelitian ini merupakan penelitian analitik observasional dengan rancangan cross sectional secara retrospektif dengan menggunakan data sekunder. Subyek penelitian adalah penderita hepatoseluler karsinoma yang telah menjalani pemeriksaan CT-Scan Abdomen 4 fase di Instalasi radiologi RSUP Dr Sardjito dalam kurun waktu Januari 2021 - Desember 2022, terkonfirmasi dari hasil patologi anatomi, serta memiliki pemeriksaan darah albumin dan bilirubin. Subyek penelitian diambil dengan menggunakan metode consecutive non-random sampling. Hasil : Dari 32 sampel penelitian, sebagian besar terdiri dari laki-laki (62,50%), rentang usia subyek penelitian paling banyak adalah usia ? 60 (53%), nilai serum albumin terbanyak pada nilai < 3 xss=removed xss=removed> 0.05) yang menandakan bahwa korelasi antara gambaran CT hepatoseluler karsinoma dengan skor ALBI tidak bermakna secara statistic. Kesimpulan : Tidak terdapat korelasi yang bermakna secara statistik antara gambaran hepatoseuler karsinoma berdasarkan skor BCLC dengan skor ALBI (p = 0.11).

Background :Hepatocellular carcinoma ranks as the fifth leading cause of death from malignant tumors in Asia. The 5-year survival rate for hepatocellular carcinoma is 18%, making it the second most deadly tumor. The ALBI score is one of the determining factors in the prognosis of hepatocellular carcinoma. Objective :The aim of this study was to prove the correlation between the ALBI score and the CT radiological appearance of hepatocellular carcinoma based on BCLC in hepatocellular carcinoma patients. Materials and Methods:This research is an observational analytical study with a retrospective cross sectional design using secondary data. The research subjects were hepatocellular carcinoma sufferers who had undergone a 4-phase abdominal CT-Scan examination at the radiology installation of Dr Sardjito Hospital in the period January 2021 - December 2022, confirmed by anatomical pathology results, and had albumin and bilirubin blood tests. Research subjects were taken using the consecutive non-random sampling method. Results :Of the 32 research samples, most of them consisted of men (62.50%), the age range of research subjects was mostly age ? 60 (53%), the highest serum albumin value was < 3 xss=removed xss=removed> 0.05) indicating that the correlation between the CT image of hepatocellular carcinoma and the ALBI score was not statistically significant. Conclusion :There was no statistically significant correlation between the appearance of hepatocellular carcinoma based on the BCLC score and the ALBI score (p = 0.11).

Kata Kunci : Hepatoseluler karsinoma, BCLC, Skor ALBI, Hepatocellular carcinoma, BCLC, ALBI score