Hubungan Antara Kesesuaian Terapi Antibiotik Empiris Dan Kadar Procalcitonin Pada Pasien Covid-19 Yang Disertai Dengan Infeksi Sekunder Bakteri Paru Di ICU RSUP Dr Sardjito

Febrian Naufaldi, dr. Calcarina Fitriani R.W.,Sp.An, KIC.; dr. Akhmad Yun Jufan, SpAn,M.Sc., KIC

2023 | Tesis-Spesialis | S2 Anestesiologi

Latar Belakang: Coronavirus disease 2019 (COVID-19) adalah penyakit pneumonia yang disebabkan oleh severe acute respiratory syndrome coronavirus 2 (SARS CoV 2). Insiden terjadinya infeksi sekunder bakteri paru sekitar 3% sampai 30%. Karena fenotipe klinis yang serupa dan kesulitan dalam mengidentifikasi penyakit COVID-19 dengan infeksi sekunder bakteri atipikal atau infeksi sekunder nosokomial beberapa pedoman menyarankan penggunaan antibiotik empiris. Procalcitonin umumnya dianggap sebagai biomarker infeksi bakteri sistemik dan telah ditafsirkan sebagai indikator infeksi bakteri sekunder pada COVID-19. Tujuan: Mengetahui hubungan antara kesesuaian terapi antibiotik empiris dengan hasil kadar procalcitonin pada pasien covid-19 yang disertai dengan infeksi sekunder bakteri paru di ICU RSUP Dr Sardjito. Metode Penelitian: Penelitian ini menggunakan rancangan penelitian observasional kohort retrospektif yang menilai hubungan antara kesesuaian terapi antibiotik empirik dan kadar procalcitonin pada pasien COVID-19 dengan infeksi sekunder bakteri paru di RSUP Dr. Sardjito. Besar sampel adalah 40 pasien yang menjalani perawatan ICU dengan diagnosis COVID-19 dengan infeksi sekunder bakteri paru. Hasil penelitian: Penelitian dilakukan selama 3 bulan dengan hasil Pasien yang sensitif terhadap antibiotik empiris mengalami kadar procalcitonin <0 p=0,026. OR=2,06>

Background: Coronavirus disease 2019 (COVID-19) is pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS CoV 2). Incident happening infection secondary bacteria lungs about 3% to 30%. Because of the phenotype similar clinical trials and difficulties in identify COVID-19 disease with infection secondary bacteria atypical or infection secondary nosocomial a number of guidelines recommend use antibiotics empirical. Procalcitonin generally considered as a biomarker of infection bacteria systemic and has interpreted as indicator infection bacteria secondary to COVID-19. Purpose: The aim of this study was to determine the relationship between the suitability of empiric antibiotic therapy and the results of procalcitonin levels in accompanied Covid-19 patients with secondary bacterial lung infection in ICU Dr Sardjito Hospital. Research methods: This study used a retrospective observational cohort study design that assessed the relationship between the suitability of empiric antibiotic therapy and procalcitonin levels in COVID-19 patients with secondary bacterial lung infections at Dr. Sardjito. The sample size was 40 patients undergoing ICU care with a diagnosis of COVID-19 with secondary bacterial lung infection. Results: The study was conducted for 3 months and the results showed that patients who were sensitive to empiric antibiotics experienced procalcitonin levels <0 xss=removed OR=2.06>

Kata Kunci : ICU, COVID-19, Infeksi sekunder, Antibiotik, Prokalsitonin, Uji sensitivitas, Secondary infection, Antibiotics, Procalcitonin, Sensitivity test