FORMULASI NUTRASETIKAL JELLY CANDY EKSTRAK HERBA PEGAGAN (Centella asiatica (L.) Urb.) DENGAN VARIASI KADAR GLUKOMANAN DAN KAPPA-CARRAGEENAN BESERTA UJI AKTIVITAS ANTIOKSIDAN
Dwitya Nurlistyo Devi, apt. Marlyn Dian Laksitorini, M.Sc., Ph.D.; Dr. apt. Nunung Yuniarti, S.F., M.Si.
2023 | Skripsi | FARMASI
Permasalahan
penurunan daya ingat dan fungsi kognitif seiring bertambahnya usia menjadi hal krusial.
Pegagan berpotensi menjadi suplemen kesehatan
dengan kandungan antioksidan terpenoid dan flavonoid untuk
melindungi syaraf otak dan meningkatkan memori spasial. Inovasi jelly candy
merupakan alternatif bagi masyarakat dengan kesulitan menelan tablet.
Penelitian ini bertujuan untuk mengevaluasi pengaruh variasi kadar glukomanan
dan kappa-karagenan terhadap karakteristik fisik serta daya antioksidan jelly
candy ekstrak herba pegagan.
Penelitian
dilakukan secara eksperimental. Ekstrak herba pegagan diperoleh melalui metode
maserasi dengan pelarut etanol 70%. Aktivitas antioksidan ekstrak tersebut diuji
dengan metode reduksi DPPH dan diformulasikan dalam sediaan jelly candy.
Uji karakteristik fisik jelly candy meliputi organoleptis, keseragaman
bobot, loss on drying, pH, dan elastisitas. Respon uji karakteristik
fisik dianalisis dan dioptimasi menggunakan Design Expert 13 dengan
metode Simplex Lattice Design. Hasil respon formula optimal dianalisis
dengan one-sample t-test SPSS 25.
Hasil menunjukkan bahwa kombinasi gelling agent berpengaruh terhadap peningkatan keseragaman bobot, elastisitas, dan loss on drying. Formula optimal jelly candy dengan komposisi kappa-karagenan 1,33?n glukomanan 0,67% memiliki aktivitas antioksidan sebesar 197,49 ppm. Verifikasi respon karakteristik fisik formula optimal terkait keseragaman bobot, elastisitas, dan loss on drying terbukti tidak berbeda signifikan (p>0,05) dari nilai prediksi dari Design Expert 13.
The
problem of decreasing memory and cognitive function with age becomes crucial. Centella
asiatica has the potential to be a health supplement containing terpenoid
and flavonoid antioxidants to protect brain nerves and improve spatial memory.
Jelly candy innovation is an alternative for people who have difficulty
swallowing tablets. This study aims to evaluate the effect of varying levels of
glucomannan and kappa-carrageenan on the physical characteristics and
antioxidant power of jelly candy extract of the gotu kola herb. The
research was conducted experimentally. Centella
asiatica herb extract was obtained by maceration with 70%
ethanol. The antioxidant activity of the extract was tested using the DPPH
reduction and formulated into jelly candy. Physical characteristics of jelly
candy include organoleptic, weight uniformity, loos on drying, pH, and
elasticity. Physical characteristic responses were optimized using Design
Expert 13 with Simplex Lattice Design. The results of the optimal formula
response were analyzed by one-sample t-test SPSS 25. The
results showed that kappa-carrageenan and glucomannan affected increasing the
uniformity of weight, elasticity, and loss on drying. The optimal
formula for jelly candy with a composition of 1.33% kappa-carrageenan and 0.67%
glucomannan has an antioxidant activity of 197.49 ppm. Verification of the
response of the optimal formula physical characteristics proved not
significantly different (p>0.05) from the predicted value of Design Expert
13.
Kata Kunci : Kata kunci: Pegagan, antioksidan, jelly candy, kappa karagenan-glukomanan. / Keywords: Gotu Kola, antioxidant, jelly candy, kappa carrageenan-glucomannan.