Korelasi Derajat White Matter Hyperintensity Dengan Volume Hippocampus Pada MRI Volumetrik Cerebral Pasien Demensia

LALU BAYU ERDIAN RAHARJA, dr. Yana Supriatna, Ph.D, Sp.Rad (K); dr. Hesti Gunarti, Sp.Rad (K)

2023 | Tesis-Spesialis | S2 Radiologi

Tujuan : Penelitian ini untuk mengetahui korelasi derajat white matter hyperintensity (WMH) dengan volume hippocampus pada MRI volumetrik cerebral pasien demensia.

Metode : Penelitian ini merupakan penelitian cross-sectional dengan pengambilan data secara retrospektif dari data sekunder pasien klinis demensia yang dilakukan MRI volumetrik cerebral pada Januari 2020 - Januari 2022. Pengambilan sampel secara consecutive non-random sampling. Subjek terpilih sesuai kriteria inklusi dan eksklusi. Dilakukan penilaian derajat white matter hyperintensity dan hasilnya dikorelasikan dengan volume hippocampus.

Hasil : Jumlah sampel 33 subjek. Sebagian besar berjenis kelamin laki-laki sebanyak 20 subjek (61%). Sebaran usia didominasi kelompok 65-70 tahun (52%). Sebagian besar subjek memiliki tekanan darah kategori hipertensi (79%) dengan IMT kategori normal (79%). Jumlah subjek terbanyak pada demensia vaskular (52%) diikuti demensia Alzheimer (24%) dan demensia mixed type (18%), dengan paling sedikit demensia unspecified (6%). Pada sebagian besar subjek memiliki derajat white matter hyperintensity Fazekas 1 diikuti derajat Fazekas 2 baik pada periventricular white matter maupun deep white matter.

Kesimpulan : Didapatkan hubungan yang bermakna secara statistik antara derajat white matter hyperintensity dengan volume hippocampus dengan nilai negatif pada periventricular white matter (p = 0,024 ; r = -0,346) dan deep white matter (p = 0,026 ; r = -0,340).

Objective : This study was to determine the correlation between the degree of white matter hyperintensity (WMH) and hippocampal volume in cerebral volumetric MRI of dementia patients.

Methods: This study is a cross-sectional study with retrospective data collection from secondary data of dementia clinical patients who underwent cerebral volumetric MRI in January 2020 - January 2022. Consecutive non- random sampling was taken . Subjects were selected according to the inclusion and exclusion criteria. The degree of white matter hyperintensity was assessed and the results were correlated with the hippocampal volume.

Results: The number of samples is 33 subjects. Most of them were male as many as 20 subjects (61%). The age distribution was dominated by the 65-70 year old group (52%). Most of the subjects had blood pressure in the hypertension category (79%) with normal BMI (79%). The highest number of subjects had vascular dementia (52%) followed by Alzheimer's dementia (24%) and mixed type dementia (18%), with the least amount of unspecified dementia (6%). Most of the subjects had white matter hyperintensity degree Fazekas 1 followed by degree Fazekas 2 both in the periventricular white matter and deep white matter.

Conclusion: There was a statistically significant relationship between the degree of white matter hyperintensity and hippocampal volume with negative values in the periventricular white matter (p = 0.024 ; r = -0.346) and deep white matter (p = 0.026 ; r = -0.340).

Kata Kunci : dementia, Fazekas, hippocampus, white matter hyperintensity, volumetric MRI