KORELASI NILAI VOLUMETRIK MRI HIPPOCAMPUS DAN CEREBELLUM DENGAN GAMBARAN EEG PENDERITA EPILEPSI

PUTRI ATMANI S, Dr. dr. Lina Choridah, Sp. Rad (K) PRP; dr. Sri Retna Dwidanarti, Sp. Rad (K) Onk

2022 | Tesis-Spesialis | RADIOLOGI

Tujuan: Penelitian ini bertujuan untuk mengetahui korelasi nilai volumetrik MRI hippocampus dan cerebellum dengan gambaran EEG pasien epilepsi. Metode: Penelitian ini merupakan jenis penelitian observasional analitik korelatif dengan desain penelitian cross sectional. Pengambilan data dilakukan secara retrospektif dari data sekunder pasien dengan pengantar klinis epilepsi yang dilakukan pemeriksaan MRI kepala volumetrik di Instalasi Radiologi RSUP Dr. Sardjito Yogyakarta pada bulan November 2018 sampai bulan Februari 2022. Pengambilan sampel dilakukan secara consecutive non-random sampling. Subjek terpilih sesuai dengan kriteria inklusi dan eksklusi. Dilakukan penilaian volumetrik hippocampus dan cerebellum dengan MRI, dan hasilnya dikorelasikan dengan tipe gelombang EEG pada pasien. Hasil: Jumlah sampel sebanyak 32 pasien diikutsertakan dalam penelitian ini. Rerata volume hippocampus EEG normal 7,49 ± 1,08 cm3, EEG tipe sharp 6,99 ± 1,40 cm3, dan EEG spike and wave sebesar 8,01 ± 1,27 cm3 (p=0,402). Rerata volume cerebellum pada EEG normal 124,64 ± 20,87 cm3, EEG sharp sebesar 122,18 ± 15,84 cm3, dan EEG spike and wave sebesar 126,34 ± 14,60 cm3 (p=0,935). Dari analisis bivariat One Way Anova, tidak ditemukan perbedaan bermakna antara rerata nilai volumetrik MRI hippocampus dan cerebellum dengan gambaran EEG, dengan nilai p masing-masing sebesar 0,402 dan 0,935. Kesimpulan: Rerata nilai volumetrik hippocampus dan cerebellum tertinggi pada EEG Spike and Wave, rerata nilai volumetrik cerebellum dan cerebellum terendah pada EEG Sharp. Tidak ditemukan hubungan yang bermakna secara statistik antara nilai volumetrik MRI hippocampus maupun cerebellum terhadap gambaran EEG penderita epilepsi.

Objectives: This study aims to determine the correlation of hippocampus and cerebellum MRI volumetric values with EEG images in epilepsy patients. Method: This was an analytic observational study with a cross-sectional research design. Data collection was carried out retrospectively from secondary data of patients with an introduction to the clinical epilepsy who underwent a volumetric head MRI examination at the Radiology Installation of RSUP Dr. Sardjito Yogyakarta from November 2018 to February 2022. Sampling was carried out using consecutive non-random sampling. Subjects were selected according to the inclusion and exclusion criteria. Volumetric assessment of the hippocampus and cerebellum was carried out with MRI and the results were correlated with the type of EEG waves in the patient Result: A total sample of 32 patients was included in this study. The normal EEG hippocampus volume mean was 7.49 ± 1.08 cm3, the sharp type EEG was 6.99 ± 1.40 cm3, and the spike and wave EEG was 8.01 ± 1.27 cm3 (p=0.402). The mean volume of the cerebellum on a normal EEG was 124.64 ± 20.87 cm3, a sharp EEG was 122.18 ± 15.84 cm3, and spike and wave EEG was 126.34 ± 14.60 cm3 (p=0.935). From bivariate One Way Anova analysis, there was no significant difference between the mean volumetric MRI values of the hippocampus and cerebellum and EEG images, with p values of 0.402 and 0.935 respectively. Conclusion: The highest mean hippocampus and cerebellum volumetric values were on the EEG Spike and Wave, the lowest mean cerebellum and cerebellum volumetric values were on EEG Sharp. There was no statistically significant relationship between volumetric MRI values of the hippocampus and cerebellum on the EEG appearance of epileptic patients.

Kata Kunci : Kata kunci: EEG, Epilepsi, MRI, volume hippocampus, volume cerebellum