A SYSTEMATIC REVIEW OF DENGUE VECTOR Aedes spp. RESISTANCE TO PERMETHRIN INSECTICIDE

NANDHINSANIA A M, Prof. dr. Tri Baskoro Tunggul Satoto, M. Sc., Ph. D; dr. Tridjoko Hadianto, DTM & H., M.Kes

2022 | Skripsi | S1 KEDOKTERAN

Pendahuluan Demam dengue adalah suatu penyakit yang terjadi di seluruh dunia dengan kenaikan angka kejadian dan kematian. Untuk mengurangi dan mengontrol kejaidan demam dengue, insektisida jenis permetrin digunakan sebagai vektor kontrol. Penggunaan jangka panjang insektisida menyebabkan adanya kerentanan insektisida yang terjadi di nyamuk. Tujuan Untuk mempelajari status kerentanan dan mekanisme Aedes spp. terhadap insektisida permetrin Metode Telaah keritis digunakan dalam penelitian ini. Jurnal didapat dari PubMed berdasarkan kata kunci, kriteria inklusi dan ekslusi. Kriteria inklusi meliputi jurnal berhabas inggris, jurnal bebas berbayar, dan jurnal yang dipublikasikan pada tahun 2020-2021. Hasil 146 jurnal didapatkan dari PubMed berdasarkan kata kunci dan 126 jurnal dieklusi dikarenakan tidak relevan dengan kriteria iklusi dan ekslusi. Kerentanan vektor dengue Aedes spp. menunjukan berbagai hasil. Mekanisme kerentanan terhadap permethrin dikarenakan resistensi metabolik dan mutasi kdr Kesimpulan Aedes spp. rentan terhadap insektisida permetrin dan mayoritas mekanisme kerentanan terhadap permetrin adalah resistensi metabolik dan mutasi kdr

Background Dengue fever (DF) is a disease that happens worldwide with an increased incidence rate and high mortality rate. In an attempt to control and reduce the incidence of DF, permethrin insecticide is used for vector control. However, resistance to insecticides is emerging among mosquitoes. Aim To study the resistance status and mechanisms of Aedes spp. to permethrin insecticide. Method The method of this study is a systematic review. It was obtained from PubMed based on keywords, inclusion, and exclusion criteria. Inclusion criteria include journals or articles written in English, free-access articles, and published from the year 2020-2021. Result There were 146 journal articles obtained from PubMed based on keywords and 126 journal articles were excluded due to not being relevant to the inclusion and exclusion criteria. The resistance status of dengue vector Aedes spp. showed different results. Resistance mechanisms to permethrin were metabolic resistance and kdr mutation in target-site resistance. Conclusion Aedes spp. resistance to permethrin insecticide and the major of resistance mechanism of Aedes spp. to permethrin were metabolic resistance and kdr mutation

Kata Kunci : Dengue, Aedes spp., Resistance status, Permethrin