HASIL GUNA KOMBINASI H2O2 3% DENGAN OFLOXACIN TOPIKAL DIBANDING OFLOXACIN TOPIKAL SAJA PADA PENGOBATAN OTITIS MEDIA SUPURATIF KRONIS BENIGNA AKTIF

DEONI DANISWARA, dr. D.A. Edhie Samodra Sp.THTKL(K).; Dr. dr. Luh Putu Lusy Indrawati. Sp.THTKL(K). M.Kes.

2021 | Tesis-Spesialis | ILMU KESEHATAN TELINGA HIDUNG TENGGOROK BEDAH KEPALA DAN LEHER

Latar Belakang : Angka kejadian OMSK masih tinggi serta masih lamanya perawatan menjadi inti utama permasalahan pada studi ini. Kegagalan terapi antimikroba topikal biasanya karena tatacaranya yang tidak tepat dan resistensi bakteri. Secara khusus, yaitu kegagalan antibiotik topikal untuk mencapai lokasi infeksi tertentu yang tepat di telinga tengah. Tujuan: Menentukan hasil guna H2O2 3% sebagai terapi tambahan pada otitis media supuratif kronis benigna aktif. Metode : Rancangan penelitian yang digunakan adalah Randomize Control Trial Single Blind. Pasien yang terdiagnosis OMSK dilakukan pemeriksaan fisik THT, melihat apakah ada otorea atau tidak. Subyek dalam penelitian ini adalah penderita OMSK benigna aktif yang datang ke poliklinik Ilmu Kesehatan Telinga Hidung Tenggorok RSUP Dr. Sardjito Yogyakarta dari bulan Oktober 2019 sampai Februari 2020 yang memenuhi kriteria inklusi dan ekslusi sampai jumlah sampel terpenuhi. Subyek dibagi menjadi 2 kelompok yaitu yang menerima ofloxacin topikal saja dan yang menerima ofloxacin topical dan H2O2 3%. Hasil : Subyek penelitian sebanyak 50 orang. Telinga yang mendapat perlakuan ofloxacin saja, ada 12(48%) orang tidak keluar cairan dan ada 13 (52%) orang yang keluar cairan sedangkan yang mendapat ofloxacin topical dan H2O2 3% ada 20 (80%) orang yang tidak keluar cairan dan ada 5 (20%) orang yang keluar cairan. Secara statistik menunjukan perbedaan signifikan (0,018; p=0,05) dan nilai OR 4,333. Kesimpulan : Hal ini membuktikan bahwa pemberian ofloxacin topikal saja dengan ofloxacin & H2O2 3% secara statistik menunjukan perbedaan signifikan (0,018; p=0,05) terhadap kejadian otorea dan secara klinis menunjukan bahwa pemberian ofloxacin topical dan H2O2 3% memungkinan untuk tidak terjadinya otorea sebanyak 4,3 kali dibanding ofloxacin topical saja.

Background : The incidence of CSOM is still high and the length of treatment is the main problem in this study. The failure of topical antimicrobial therapy is usually due to inappropriate treatment and bacterial resistance. Specifically, the failure of topical antibiotics to reach the exact site of infection in the middle ear. Objective: Determining the use of 3% H2O2 as adjunctive therapy in active benign chronic suppurative otitis media. Methods : The research design used was a Single Blind Randomized Control Trial. Patients diagnosed with CSOM were subjected to a physical examination of the ENT, to see if there was otorrhoea or not. The subjects in this study were patients with active benign CSOM who came to the Ear Nose Throat Health Sciences polyclinic, RSUP Dr. Sardjito Yogyakarta from October 2019 to February 2020 who met the inclusion and exclusion criteria until the number of samples was met. Subjects were divided into 2 groups, namely those who received topical ofloxacin only and those who received topical ofloxacin and 3% H2O2. Results : The research subjects were 50 people. Ears that were treated with ofloxacin alone, there were 12 (48%) people who did not come out of fluid and there were 13 (52%) people who had discharge while those who received ofloxacin topical and 3% H2O2 there were 20 (80%) people who did not come out and there was 5 (20%) people who have discharge. Statistically it showed a significant difference (0.018; p=0.05) and the OR value was 4.333. Conclusion : This proves that the administration of topical ofloxacin alone with ofloxacin & 3% H2O2 statistically shows a significant difference (0.018; p=0.05) on the incidence of otorrhoea and clinically shows that administration of topical ofloxacin and 3% H2O2 may prevent otorrhoea as much as 4, 3 times that of topical ofloxacin alone.

Kata Kunci : h2o2 3%,OMSK, Otorhea, benign active chronic suppurative otitis media, 3% H 2 O 2 , topical ofloxacin