KORELASI KADAR PEPSIN PADA KAVUM ORIS TERHADAP GEJALA DAN TANDA PASIEN REFLUKS LARINGOFARING

NUR CHOLIDA HARISSA, dr. Kartono Sudarman, Sp.T.H.T.K.L.(K); dr. Agus Surono, Ph. D., M. Sc., Sp.T.H.T.K.L.(K)

2021 | Tesis-Spesialis | ILMU KESEHATAN TELINGA HIDUNG TENGGOROK BEDAH KEPALA DAN LEHER

Latar Belakang: Refluks laringofaring (RLF) didefinisikan sebagai aliran balik cairan lambung ke daerah laring dan faring sehingga menimbulkan gejala saluran aero digestif atas yang beragam. RLF terjadi pada sekitar 4% hingga 10% pasien yang melakukan pemeriksaan ke dokter Telinga Hidung Tenggorok (THT). Tujuan Penelitian: Penelitian ini bertujuan untuk menentukan korelasi kadar pepsin pada saliva di kavum oris terhadap gejala dan tanda pasien refluks laringofaring. Metode Penelitian: Jenis penelitian ini adalah analitik observasional crosssectional. Dilakukan pemeriksaan reflux symptom index (RSI) dan reflux finding score (RFS) pada 30 subyek penelitian di Poli Rawat Jalan THT-KL RSUP Dr.Sardjito Yogyakarta mulai Agustus-Desember 2020, kemudian dilakukan pemeriksaan kadar pepsin saliva dengan Teknik ELISA lalu dilakukan uji Spearman's Rho. Hasil: Dari 30 responden yang terdiri dari laki-laki 15 orang (50%) dan perempuan 15 orang (50%), didapatkan kelompok usia terbanyak 48 - 57 tahun (26,7%), dengan rata-rata usia 42,60±14,47 tahun. Nilai rerata RSI 14,73±2,64 , nilai rerata RFS 9,10±2,12 , dan pada semua sampel didapatkan pepsin (+) dengan nilai rerata kadar pepsin saliva 40,83±56,47 ng/ml.Ada korelasi positif antara RSI dan pepsin saliva namun tidak bermakna secara statistik. Ada korelasi positif antara RFS dan pepsin saliva (p<0,05) serta korelasi positif antara RSI dan RFS(p<0,05). Kesimpulan: Terdapat korelasi positif antara kadar pepsin saliva dengan RSI, namun tidak bermakna secara statistik. Terdapat korelasi positif antara kadar pepsin saliva dengan RFS dan secara statistik bermakna.

Background: Laryngopharyngeal reflux (RLF) is defined as the backflow of gastric fluid into the larynx and pharynx, causing various upper aerodigestive tract symptoms. RLF occurs in about 4% to 10% of patients who see an Ear Nose Throat (ENT) doctor. Objectives: This study aimed to determine the correlation of pepsin levels in saliva in the oral cavity to the symptoms and signs of patients with laryngopharyngeal reflux. Methods: This type of research is an analytic cross-sectional observation. The reflux symptom index (RSI) and reflux finding score (RFS) were examined on 30 research subjects at the ENT Outpatient Clinic, Dr. Sardjito Hospital Yogyakarta starting from August-December 2020, then the salivary pepsin level was checked with the ELISA technique and then the Spearman's Rho test was carried out. Results: Of the 30 respondents consisting of 15 men (50%) and 15 women (50%), the highest age group was 48 -57 years (26.7%), with an average age of 42.60±14.47 years. The mean value of RSI is 14.73±2.64, the mean value of RFS is 9.10±2.12, and in all samples pepsin (+) is obtained with the mean salivary pepsin level of 40.83±56.47 ng/ml. There was a positive correlation between RSI and salivary pepsin, but it was not statistically significant. There was a positive correlation between RFS and salivary pepsin (p<0.05) and a positive correlation between RSI and RFS (p<0.05). Conclusion: There is a positive correlation between salivary pepsin levels and RSI, but it is not statistically significant. There is a positive correlation between salivary pepsin levels and RFS, and it is statistically significant.

Kata Kunci : refluks laringofaring, reflux symptom index, reflux finding score, pepsin saliva