Korelasi antara Morfologi Ultrasonografi dengan Derajat Diferensiasi (grade) Karsinoma Duktal Invasif Payudara

ANGGIT YOSO S, Dr. dr. Lina Choridah, Sp.Rad (K).; DR. Sudarmanta, Sp.Rad (K) RI

2021 | Tesis-Spesialis | RADIOLOGI

Pendahuluan : Karsinoma duktal invasif merupakan salah satu dari karsinoma invasif payudara yang paling umum. Ultrasonografi (USG) merupakan modalitas pencitraan yang dapat memvisualisasikan massa payudara bersifat jinak atau ganas berdasarkan the Breast Imaging Reporting And Data System (BI-RADS) - Ultrasound lexicon. Temuan histologi bersamaan dengan temuan morfologi USG pada beberapa penelitian diperkirakan dapat menjadi indikator prognostik untuk menentukan derajat diferensiasi keganasan pada karsinoma payudara namun, menunjukkan hasil yang berbeda - beda. Tujuan : Mengetahui korelasi antara temuan morfologi USG dengan derajat diferensiasi (grade) karsinoma duktal invasif payudara. Metode : Penelitian ini merupakan penelitian observasional analitik uji korelasi, potong lintang pada 1 Januari 2017 - 31 Desember 2020. Temuan massa USG dikorelasikan dengan derajat diferensiasi histologis karsinoma duktal invasif payudara dengan nilai signifikansi p < 0.05. Hasil : Tidak ada hubungan antara temuan morfologi USG berupa bentuk (p =0.752, r = -0,045), orientasi (p = 0.873, r = -0.023), batas (p = 0.602, r = -0.074), ekhogenitas (p = 0.745, r = -0.046), kalsifikasi (p = 0.579, r = -0,079), fitur posterior (p = 0.151, r = -0,202), fitur terkait (p = 0.393, r = 0,121), dan kasus khusus (p = 0.206, r = 0,178) dengan derajat diferensiasi karsinoma duktal invasif payudara. Kesimpulan : Tidak didapatkan korelasi yang bermakna antara morfologi USG dengan derajat diferensiasi (grade) karsinoma duktal invasif payudara, sehingga morfologi USG belum dapat dijadikan indikator prognostik pada karsinoma duktal invasif payudara.

Introduction: Ductal invasive carcinoma is one of the most common invasive breast carcinomas. Ultrasonography (USG) is widely used to visualize and differentiate benign or malignant breast mass based on the Breast Imaging Reporting And Data System (BI-RADS) - Ultrasound lexicon. Histologic and USG morphology findings suggested as a prognostic indicator to determine the malignancy differentiation degree in breast carcinoma showing different results in several studies. Aim: This study s investigates the correlation between ultrasonography morphology findings with ductal invasive breast carcinoma differential degree (grading). Method: This is an observational analytical corelation study with a cross- sectional design from January 1st, 2017, to December 31st, 2020. The sonographic findings of ductal invasive breast carcinoma were correlated with their histopathologic grades, with p < 0.05 considered significant. Result : No correlation was found between USG morphological findings on shape (p = 0.752, r = -0,045), orientation (p = 0.873, r = -0.023), margin (p = 0.602, r = -0.074), echogenity (p = 0.745, r = -0.046), calsification (p = 0.579, r = -0,079), posterior feature (p = 0.151, r = -0,202), associated feature (p = 0.393, r = 0,121), and special case (p = 0.206, r = 0,178) with differential degree (grading) of ductal invasive breast carsinoma. Conclusion: No significant correlation was found between USG morphology findings with ductal invasive breast carcinomas differential degree (grading); therefore, it can not be used as a prognostic indicator yet.

Kata Kunci : Karsinoma Duktal Invasif Payudara, Ultrasonografi, Temuan fitur morfologi, derajat diferensial (grade), indikator prognostik, Ductal Invasive Breast Carcinoma, Ultrasonography, Morphological Feature findings, Differential degree (grading), prognostic indi