PERBEDAAN KADAR KOLINESTERASE BERDASARKAN KEBERADAAN ASITES PADA PENDERITA SIROSIS HATI

FADHILA PLATANIA, Dr. dr. Neneng Ratnasari, SpPD-KGEH; dr. Catharina Triwikatmani, M.Kes. SpPD-KGEH

2019 | Skripsi | S1 KEDOKTERAN

Sirosis hati merupakan penyakit hati kronis yang memiliki morbiditas dan mortalitas yang tinggi. Patogenesis sirosis hati diawali dengan proses peradangan dan nekrosis sel hati, yang diikuti dengan proses pembentukan jaringan ikat dan regenerasi nodul. Kerusakan arsitektur hati ini akan menyebabkan terganggunya sirkulasi mikro dan makro pada hati. Asites merupakan manifestasi cardinal dari sirosis hati dimana 80% penderita sirosis hati di Amerika mengalami asites. Pengukuran aktivitas enzim kolinesterase pada serum dapat membantu menilai fungsi sintesis hati, penyakit hati kronis dan kondisi hipoalbuminemia karena fungsi albumin sebagai protein pengangkut kolinesterase. Oleh karena itu, kadar kolinesterase diduga dapat digunakan untuk memprediksi munculnya asites sebagai komplikasi dari sirosis hati.

Liver cirrhosis is a chronic liver that has high mortality and morbidity. The pathogenesis of liver cirrhosis begins with wide inflammation and necrosis of liver cells, the formation of fibrous tissues and the attempt to form regenerative nodules. The distorted liver architecture then causes changes in the macro and micro circulation. Ascites is a cardinal manifestation of liver cirrhosis, which is defined as an accumulation of serous fluid in the peritoneal cavity. Eighty percent of liver cirrhosis patients in America present with ascites. The measurement of serum cholinesterase activity helps to assess liver synthetic function. A reduction of serum cholinesterase activities has been found in conditions which cause reduction of liver synthetic function, chronic liver diseases and hypoalbuminemia due to the role of albumin as cholinesterase's transporter protein. As such, the amount of cholinesterase may be used to predict ascites complication in liver cirrhosis patients.

Kata Kunci : kadar kolinesterase, asites, sirosis