Pengaruh Ekstrak Centella asiatica sp. terhadap Cedera Tubulus, Ekspresi Vimentin dan E-cadherin pada Mencit dengan Nefrektomi Subtotal 5/6

KEMALA ATHOLLAH, dr. Nur arfian, Ph.D ; Dr. dr. Dwi Cahyani Ratna Sari, M.Kes, PA (K)

2017 | Skripsi | S1 PENDIDIKAN DOKTER

Gagal ginjal kronis dapat terjadi karena vasokonstriksi berkepanjangan yang mengganggu aliran darah, menyebabkan cedera tubulus dan fibrosis. Cedera tubulus karena kerusakan kapiler peritubular yang menyebabkan hipoksia sel tubulus akan mengakibatkan apoptosis atau transdiferensiasi epitel-mesenkimal. Asiatic acid, aaiaticoside dan SM2 pada Centella asiatica sp. terbukti menurunkan angka kematian sel saraf akibat H2O2 dan mengurangi konsentrasi radikal bebas intraseluler. Belum diketahui pengaruh ekstrak Centella asiatica sp. terhadap cedera tubulus

Chronic kidney disease may occur due to prolonged vasoconstriction which impair renal blood flow, this will lead to nephron loss, tubular injury and fibrosis. Tubulointerstitial injury that caused by peritubular capilary damage, will lead to hipoxia of tubular cell and apoptosis then epithelial-mesenchymal transition process. Centella asiatica that consist of asiatic acid, asiaticoside and SM2 has proved can decrease cell death caused by H2O2 and free radical activity in cell. There is no proof about effect of extract Centella asiatica in tubular injury

Kata Kunci : Nefrektomi subtotal 5/6, Centella asiatica sp., cedera tubulus, vimentin, e-cadherin