ENKAPSULASI VITAMIN C DALAM KITOSAN–PATI/ASAM SITRAT DAN STUDI FAKTOR–FAKTOR YANG MEMPENGARUHI SISTEM PELEPASANNYA; ENCAPSULATION OF VITAMIN C IN CHITOSAN–STARCH/CITRIC ACID AND STUDY ON THE FACTORS AFFECTING ITS RELEASE SYSTEM
MAHLANI, APRINA SUCI, Mudasir
2016 | Disertasi | FMIPAEncapsulation of vitamin C using chitosan–starch/citric acid has been synthesized using ionic gelation method. This study aims to determine release kinetics of encapsulated vitamin C and factors that affecting the release. Chemical changes, morphology and particle size of the materials were characterized by FTIR and TEM. In vitro release study was conducted by dispersing the material in the PBS pH 7,4 and aquabidest for 7 hours. The concentration of vitamin C was determined by UV–VIS spectrophotometer. The release kinetics of vitamin C were studied by zero order, first order, Higuchi and Korsmeyer–Peppas models. The factors that affect the release system of vitamin C were studied by Taguchi method. The result of FTIR characterization showed that characteristic absorption peaks of chitosan were shifted. This indicates that there were interactions of functional groups of chitosan with starch and citric acid. Analysis of particle size by TEM showed that the material formed aggregates. The results of in vitro release study in PBS pH 7.4 showed that products with the formula F1.1a and F1.3a tend to follow Korsmeyer–Peppas kinetic model, while F1.2a and F1.4a tend to follow zero order kinetic model. In aquabidest, product of formula F1.1b and F1.2b tend to follow zero order kinetic model, while F1.3b and F1.4b tend to follow first order kinetic model. The factor that mostly influence the release of encapsulated vitamin C in chitosan–starch/citric acid was the cross linker of citric acid.
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