STUDI IN VITRO PELEPASAN KURKUMIN DARI MEMBRAN MAKROPORI KITOSAN–KARAGINAN DENGAN MENGGUNAKAN SILIKA SEBAGAI POROGEN;IN VITRO STUDY OF CONTROLLED RELEASE CURCUMIN FROM CHITOSAN–CARRAGEENAN MACROPOROUS MEMBRANE USING SILICA AS POROGEN

Roman, Fransiska D M, Dwi Siswanta

2016 | Skripsi | FMIPA

The controlled release of curcumin from chitosan–carrageenan macroporous membrane that porogen using silica had been studied. The aim of this research was to identify the effectiviness of curcumin release in a buffer:etanol (v/v). The research has studied the effect of the amount of silica, the amount of chitosan–carrageenan, the amount of stearic acid, the amount of curcumin and the variation of the medium pH toward the release of curcumin. Macroporous membrane prepared by mixing the acetic acid solution of chitosan and the aqueous solution of carrageenan, then adding stearic acid, glutaraldehyde and then added silica as porogen. The membranes were characterized by FTIR and SEM. Study on the release curcumin was conducted by soaking the curcumin loaded membrane macroporous in the buffer-ethanol solution during 6 hour and the release curcumin was measured by UV–Vis spectrophotometer. The kinetics study of releasing curcumin was analyzed by pharmacokinetics models such as zeroth order, first order, Higuchi and Korsmeyer–Peppas models. Results of FTIR analysis showed membrane before silica released led to a sharp peak absorption at 1096 cm–1 which is vibration of Si–O–Si. Meanwhile, the membrane macroporous after release of silica not rediscovered vibration asymmetry of Si–O–Si at 1096 cm–1. The result of this work showed that the optimum compositions for the film were 70% chitosan, 30% carrageenan and 150% silica which produced the optimum curcumin loading of 196 ppm and release 16.36 ppm of it during 6 hour. The pharmacokinetics model shows that the curcumin release from the macroporous membrane followed a Korsmeyer–Peppas model with rate constant (k) of 3.0945 min0.1665 and the release mechanism was dominated by diffusion process

Kata Kunci : macroporous membrane, silica, curcumin, release