STUDI IN-VITRO PELEPASAN KURKUMIN DARI MEMBRAN MAKROPORI KITOSAN-PEKTIN MENGGUNAKAN SILIKA SEBAGAI POROGEN; IN-VITRO CONTROLLED RELEASE STUDY OF CURCUMIN FROM PECTIN-CHITOSAN MACROPOROUS MEMBRANE USING SILICA AS A POROGEN

Margaretha, Fitria, Dwi Siswanta

2016 | Skripsi | FMIPA

The controlled release of curcumin from pectin-chitosan macroporous membrane had been studied. The aim of this research was identification the effectiveness of curcumin release in a buffer:etanol solution (v/v) from the macroporous membrane. The research had studied the effect of the amount of chitosan and pectin, the amount of silica, the amount of stearic acid and the variation of the medium pH toward the release rate of curcumin. Pectin-chitosan macroporous membrane was prepared by adding gluteraldehyde as crosslinker, stearic acid as emulsifier and silica as porogen. Macroporous membrane was carried into 500 ppm of curcumin solution to obtained curcumin-loaded macroporous membrane. Macroporous membrane was characterized by using SEM and FTIR spectrometer. The kinetics of releasing curcumin were analyzed by pharmacokinetics models such as zeroth order, first order, Higuchi and Korsmeyer-Peppas models. IR spectrometric characterization of pectin-chitosan macroporous membrane which before release of silica showed absorbtion bands at 1095 cm-1 and 795 cm-1 as symmetri and asymmetri stretching bands of Si-O-Si and at 463 cm-1 as bending bands of Si-O-Si. The result of characterization by SEM showed that macroporous membrane has diameter size of pores about 29.53-39.15 ?m. The result of this study showed that the released of curcumin was influenced by the amount of silica. The rate of releasing curcumin during 6 h showed that the increasing of silica addition increases the rate of releasing curcumin. For example, membrane without porogen releases 4.71% curcumin whereas the membrane added 150% of porogen could releases 9.17% during 6 h. The pharmacokinetic model shows that the curcumin release from the membrane followed a Korsmeyer-Peppas model with rate constant (k) of 1.3715 minute-0.3256 and the release mechanism was mainly dominated by Fickian difussion process.

Kata Kunci : macroporous membrane; pectin; chitosan; curcumin release