MODEL MATEMATIKA REGULASI PERBAIKAN SEL DAN SIKLUS SEL AKIBAT INFEKSI HUMAN PAPILLOMAVIRUS PADA KANKER SERVIKS; ( A MATHEMATICAL MODEL FOR CELL REPAIR AND CELL CYCLE REGULATION AFTER HUMAN PAPILLOMAVIRUS INFECTION IN CERVICAL CANCER )

Purwandani, Diana Vitelanoka, Fajar Adi Kusumo

2015 | Skripsi | FMIPA

Cervical cancer is a malignant tumor that is caused by Human Papillomavirus (HPV). The HPV infect cells in the basal layer of stratified squamous epithelia. Protein E6 and E7 of HPV respectively have the ability to inactivate p53 and pRb proteins. This leads to uncontrolled cell proliferation and DNA damage. In this thesis, the author discuss about Mathematical modeling of cell repair and cell cycle regulation as respond to DNA damage caused by HPV infection. The purpose of the discussion is to understand phenomena which happened in this regulation during HPV infection. In this thesis, Mathematical model which involve interactions between proteins as respond DNA damage have been constructed, then analyzed by Runge Kutta 4th order.

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