STUDI IN VITRO PELEPASAN KURKUMIN MENGGUNAKAN FILM PEKTIN-KITOSAN DENGAN PENGEMULSI ASAM PALMITAT IN VITRO STUDY OF CONTROLLED RELEASE OF CURCUMIN USING PECTIN-CHITOSAN FILM WITH PALMITIC ACID AS EMULSIFIER
Octaviani, Heni, Dwi Siswanta
2015 | Skripsi | FMIPAThe release of curcumin from pectin-chitosan films that have been emulsified using palmitic acid has been studied. The aim of this research was to determine the effect of curcumin loading, palmitic acid composition, ethanol concentration in solvent phosphate buffer, and pH of solvent. The films were made by mixing of pectin solution in distilled-water, chitosan solution in 1% of acetic acid solution and palmitic acid. Curcumin was added when all materials were mixed completely. Water absorption (swelling) and encapsulation efficiency (EE) in curcumin-loaded pectin-chitosan films were also determined. Curcumin release had been studied by immersing film in various of solvents for 6 hours. The concentration of curcumin released was measured using UV-Visible spectrophotometer. The results showed that the release of curcumin was influenced by loaded curcumin content in film, palmitic acid content in film, ethanol content in buffer solution, and pH of solvent. The most fit kinetic model for this experiment was of Korsmeyer-Peppas because coefficient of determination approached 1. The optimum condition for release of curcumin was achieved by film at 200 ppm of curcumin concentration and 5 mg of palmitic acid addition at 80:20 of phosphate buffer/ethanol in pH 7.
Kata Kunci : chitosan; pectin; palmitic acid; release of curcumin
