ANALISIS KESTABILAN PADA MODEL INFEKSI VIRUS HEPATITIS B DENGAN TERAPI OBAT INTERFERON

SULASTRI, Widodo

2012 | Disertasi | PROGRAM STUDI S2 MATEMATIKA

In this thesis, a mathematical model consisting of two system is designed. One system is the model with four state variables: uninfected cells, infected cells, free virus and cytotoxic cells, which represent the viral dynamics in hepatitis B virus infection during the interferon therapy. The other system is the model proposed by Nowak which describes the viral dynamics in hepatitis B virus infection after stopping the interferon treatment. The system was investigated for looking the basic reproduction number and stability of models. Simulation given ilustration figures for fixed parameter

Kata Kunci : Infeksi virus hepatitis B; terapi obat interferon; titik ekuilibrium; Basic reproduction number; kestabilan titik ekuilibrium