PREPARASI MEMBRAN KOMPLEKS POLIELEKTROLIT KITOSAN/ ?-KARAGINAN DAN APLIKASINYA UNTUK TRANSPOR KREATININ; PREPARATION OF CHIITOSAN/?-CARRAGEENAN POLYELECTROLYTE COMPLEX MEMBRANE AND ITS APPLICATION FOR CREATININE TRANSPORT

DIAN YUSTITIA, Dwi Siswanta

2014 | Disertasi | PROGRAM STUDI S-2 KIMIA

Chitosan/?-carrageenan polyelectrolyte complex (PEC) membrane has been synthesized and used for creatinine transport. The chitosan/?-carrageenan PEC membrane were prepared from the interaction between the positively charged of chitosan (?NH3 +) and the negatively charged ?-carrageenan (?OSO3 -) at 3 various ratios of composition, e.g. 40:60; 50:50 and 60:40. The MIP (Molecularly imprinted polymer) membrane has also been prepared by adding creatinine as template molecule into the membrane. The obtained membranes were characterized using Fourier Transform Infrared (FTIR) spectroscopy, Scanning Electron Microscope (SEM) and Universal Testing Machine (UTM). Creatinine transport was done by placing membrane in the middle of the chamber to separate the source phase and acceptor phase while the chamber was used as transport media. Creatinine concentrations in source phase were set at three levels, i.e.: 70; 100 and 130 ppm. The results showed that 40:60 ratio of composition of chitosan/?- carrageenan PEC membrane gives the highest creatinine percent transport, namely 39.15 %; 41.00 % and 37.2% respectively and the flux values are 6.51 × 10-4; 9.12 × 10-4 and 10.18 × 10-4 g/m2s for 70, 100 and 130 ppm of source phase concentration respectively. The MIP of chitosan/?-carrageenan PEC membrane was successes to increase membrane selectivity despite the transport percentage results are lower than non MIP membrane. The percent of creatinine transport and the flux values of MIP membrane for 70 ppm; 100 ppm; and 130 ppm of source phase concentrations, were 35.17%; 37.7%; 37.63%; and 5.33 × 10-4; 7.49 × 10-4; and 9.43 × 10-4 g/m2s, respectively. These results indicate that chitosan/?- carrageenan PEC membrane has potential to be used as a hemodialysis membrane

Kata Kunci : membran; kitosan/?-karaginan; kreatinin; transpor