SINTESIS TURUNAN KITOSAN MELALUI REAKSI CANGKOK DAN TAUT SILANG DAN APLIKASINYA SEBAGAI MEMBRAN HEMODIALISIS; SYNTHESIS OF CHITOSAN DERIVATIVES THROUGH GRAFTED AND CROSS-LINKED REACTION AND ITS APLICATION AS HEMODIALYSIS MEMBRANES

RETNO ARIADI LUSIANA, Mudasir

2014 | Tesis | PROGRAM STUDI S3 KIMIA

The main purpose of this research is to modify chitosan through substitution with active groups used for the formation of hydrogen bond with permeates which can increase the amount of carrier compounds in the membrane. In addition, substitution with an appropriate active group should be able to change to membrane surface charge so that adsorption on the surface can be reduced. Four strategies were used for this purpose: 1) grafting with chloroacetic acid as a compound having only one reactive group; (2) crosslinking using poly(ethylene glycol diglycidyl ether) p(EDGE) with two reactive groups; (3) cross-linking with citric acid which has three reactive groups; and (4) combining each compound obtained from method (1) to (3) with poly vynil alcohol (PVA) to synthesize the membrane to increase its mechanical strength. Membranes with different thickness were printed and heated to 50-70 oC. Initial characterization for the compounds produced was carried out using FTIR spectrometry, 1H-NMR, EA, TG/DTG, and SEM. Afterward, the four compounds produced by different modification methods were tested for their transport capacity for urea, creatinine, vitamin B12 and albumin. Characterization results indicate that chemical substitution has occurred in the chitosan chain to produce chitosan derivatives. Experimental results also demonstrated that the four methods used for modifying chitosan were able to increase the transport capacities as compared to the pure chitosan. The transport capacities for urea on chitosan membranes were 133,5 mg/L, on citric acid crosslinked chitosan were 287 mg/L, on p(EGDE) crosslinked chitosan were 291 mg/L, on N,O-CMC (carboxy methyl chitosan) were 260 mg/L and on N-CMC were 260 mg/L. The transport capacities for creatinine on chitosan membranes were 2,88 mg/L, on citric acid crosslinked chitosan were 7,95 mg/L, on p(EGDE) crosslinked chitosan were 6,66 mg/L, on N,O-CMC were 7,04 mg/L and on N-CMC were 6,36 mg/L. The percentage transport of vitamin B12 and albumin of the fourth membrane was 0 mg/L. The best membranes obtained on citric acid crosslinked chitosan. In general, the four types of membrane do not experience any protein adsorption on its surface, although both Vitamin B12 and albumin slightly influence the transport process of urea and creatinine

Kata Kunci : modifikasi gugus; cangkok; taut silang; membran; transpor