KINERJA SPEKTROMETER FOTOAKUSTIK INTRAKAVITAS BERSUMBERKAN LASER CO2 DALAM MENDETEKSI GAS ASETON SEBAGAI PENANDA BIOLOGIS PENYAKIT DIABETES MELLITUS DISERTAI GANGGUAN GINJAL CHRONIC KIDNEY DISEASE (CKD) MELALUI HEMBUSAN NAFAS MANUSIA; THE PERFORMANCE OF INTRACAVITY PHOTOACUSTIC SPECTROMETRER BASED ON CO2 LASER IN ACETONE GAS DETECTION AS BIOMARKERS OF DIABETES MELLITUS DISEASE WITH CHRONIC KIDNEY DISEASE (CKD) RENAL IMPAIRMENT OF HUMAN BREATH

HARJUM, Mitrayana

2013 | Disertasi | PROGRAM STUDI S2 ILMU FISIKA

Acetone gas detection has been performed in human breath use the Photoacoustic Spectrometer (PAS). PAS system used intracavity configuration by CO2 laser as the radiation source. PAS has been calibrated with an acetone gas standard, and we obtained the normalized photoacoustic signal was (0.420 ± 0.005) mV / W. By optimizing the laser power it has obtained that the lowest detection limit (BDT) was (1.310 ± 0.001) ppb. The Photoacoustic spectrometer has successfully distinguished the average of acetone gas concentration from volunteer patients with diabetes was (0.10 ± 0.09) ppm and diabetes mellitus patients with renal impairment (CKD) was (0.41 ± 0.09) ppm.

Kata Kunci : Spektrometer Fotoakustik Laser CO2; Aseton; Dibetes Mellitus; Gangguan Ginjal; Intrakavitas xii