Pengaruh kadar low density lipoprotein cholesterol (LDL-C) terhadap derajat keparahan penyakit Parkinson
NITA, dr. Subagya, Sp.S(K); dr. Abdul Gofir, Sp.S(K)
2017 | Tesis-Spesialis | SP ILMU PENYAKIT SYARAFPenyakit Parkinson (PP) adalah gangguan neurodegeneratif progresif yang berkaitan dengan usia. Beberapa penelitian terbaru menunjukan bahwa metabolisme lipid dan kolesterol berperan dalam patogenesis penyakit Parkinson. Diduga peningkatan kadar LDL-C dalam darah dapat memperbaiki kondisi klinis gejala Parkinson. Penelitian ini bertujuan untuk mengetahui pengaruh kadar LDL-C dalam darah terhadap derajat keparahan penyakit Parkinson berdasarkan skala Hoehn & Yahr. Desain penelitian ini menggunakan metode cross sectional pada pasien dengan penyakit Parkinson yang kontrol di poliklinik saraf RSUP DR Sardjito Yogyakarta, RSUD Tjitrowardoyo Purworejo, RSPAU Hardjo Lukito dan RSUP Soeradji Tirtonegoro Klaten. Empat puluh subjek yang masuk kedalam kriteria inklusi dilakukan penilaian terhadap skala Hoehn & Yahr (stadium I-V) dan pemeriksaan kadar LDL-C. Semua data dianalisis statistik secara komputerisasi. Jumlah subjek dengan stadium I sebanyak 7 (17,5%) subjek, stadium II sebanyak 18 (45%) subjek, stadium III sebanyak 14 (35%) subjek, stadium IV terdapat 1 (2,5%) subjek dan tidak ada subjek stadium V. Rerata kadar LDL-C adalah 109,55±30,31 mg/dL. Hasil analisis multivariat didapatkan pengaruh kadar LDL-C terhadap skala Hoehn & Yahr tidak signifikan (p = 0,153). Penelitian ini tidak mendukung adanya pengaruh kadar LDL-C dalam darah terhadap derajat keparahan penyakit Parkinson berdasarkan skala Hoehn & Yahr.
Parkinson's disease (PP) is a progressive neurodegenerative disorder related to age. Several recent studies have shown that lipid and cholesterol metabolism play a role in the pathogenesis of Parkinson's disease. Suspected elevated levels of LDL-C in the blood can improve the clinical condition of Parkinson's symptoms. This study aims to determine the effect of LDL-C levels in the blood on the severity of Parkinson's disease based on the Hoehn & Yahr scale. The design of this study used a cross-sectional method in patients with Parkinson's disease who came to DR Sardjito Hospital Yogyakarta, Tjitrowardoyo Hospital Purworejo, Hardjo Lukito Hospital and Soeradji Tirtonegoro Hospital Klaten. Forty subjects who entered the inclusion criteria were assessed on the Hoehn & Yahr scale (stage I-V) and examined LDL-C levels. All data are computerized statistically analyzed. The number of subjects with stage I of 7 (17.5%) subjects, stage II as many as 18 (45%) subjects, stage III as many as 14 (35%) subject, stage IV there are 1 (2.5%) subject and no subject stage V. The mean LDL-C is 109.55± 30.31 mg / dL. The result of the multivariate analysis showed that the effect of LDL-C on Hoehn & Yahr scale was not significant (p = 0,153). This study does not support the influence of blood LDL-C levels on the severity of Parkinson's disease based on the Hoehn & Yahr scale.
Kata Kunci : kadar LDL-C, derajat keparahan, penyakit Parkinson, Hoehn & Yahr
