HUBUNGAN ANTARA KADAR ALFA FETOPROTEIN DARAH PERIFER MATERNAL TERHADAP KEJADIAN PERSALINAN PRETERM

TEDDY HENDRAWAN, dr. R. Detty Siti Nurdiati, MPH, PhD, SpOG(K).; dr. Irwan Taufiqur Rachman, Sp.OG(K).

2017 | Tesis-Spesialis | SP Ilmu Kebidanan dan Penyakit Kandungan

Latar Belakang: Peningkatan kadar alfa fetoprotein serum darah maternal berkaitan dengan luaran yang buruk pada kehamilan. Terdapat hubungan antara perubahan kadar alpha fetoprotein plasma terhadap kejadian persalinan preterm. Tujuan: Mengetahui hubungan antara peningkatan kadar alfa fetoprotein pada ibu terhadap kejadian persalinan preterm. Metode: Penelitian observasional menggunakan rancangan studi nested case control. Penelitian dikerjakan dengan mengumpulkan data dari pasien bersalin yang memenuhi kriteria inklusi dan ekslusi di RSUD Sleman Yogyakarta selama kurun waktu 1 Juli 2016 sampai dengan 15 Januari 2017. Kadar alfa fetoprotein darah ibu diperiksa pada saat postpartum, serum darah tersebut dilakukan uji dengan metode ELFA (enzyme linked fluorescent assay). Setelah data terkumpul dilakukan pengolahan data dengan menggunakan chi-square. Hasil: Penelitian ini melibatkan 80 pasien yang memenuhi kriteria inklusi dan ekslusi. Pada penelitian ini kadar alfa fetoprotein tidak memiliki hubungan yang signifikan terhadap kejadian persalinan preterm p=0,065,OR 0,419. Riwayat preterm berpengaruh terhadap kejadian persalinan preterm p=0,034, OR 4,44. Ibu dengan riwayat persalinan preterm, berisiko mengalami kelahiran preterm 4,44 kali dibandingkan tanpa riwayat. Variabel yang lain tidak didapatkan perbedaan bermakna terhadap kejadian persalinan preterm (p>0,05). Kesimpulan: Peningkatan kadar alfa fetoprotein pada darah maternal ibu postpartum tidak berhubungan dengan kejadian persalinan preterm.

Background: Increased levels of alpha fetoprotein maternal blood plasma associated with poor outcomes in pregnancy. There is a relationship between changes in plasma levels of alpha fetoprotein on the incidence of preterm delivery. Objective: .Determine the relationship between elevated levels of alpha-fetoprotein in the mother on the incidence of preterm delivery. Methods: This study was observational study design (a nested case control study). Research was done by gathering data from maternity patients who meet the inclusions and exclusions criteria in the Sleman Hospital Yogyakarta from July 1 2016 until January 15 th 2017. The mother�s blood alpha-fetoprotein levels was checked at the time of post-partum. The maternal blood serum was tested by ELFA(enzyme linked fluorescent assay) method. Data was analyzed statistically with chi-square. Results: The study involved 80 patients who meet inclusion and exclusion criteria. In this study the levels of alpha-fetoprotein was not have a significant relationship to the incidence of preterm delivery p=0,065,OR 0,419. A history of preterm effect on the incidence of preterm delivery p=0,034, OR 4,44. Mothers with a history of preterm are at risk for preterm birth 4,44 times compared with no history. Another variable thai is not found significant differences (p>0,05). Conclusion: Increased levels of alpha-fetoprotein in maternal blood post partum mothers, are not associated with the incidence of preterm delivery

Kata Kunci : Persalinan preterm, Alfa fetoprotein, preterm labor, blood level alpha-fetoprotein.