HUBUNGAN ANGKA NEUTROFIL DENGAN STADIUM KLINIS PENDERITA KARSINOMA NASOFARINGS DI RSUP DR. SARDJITO

AURELIA MARIA OZORA DIOMARIZKA, Dr. dr Sagung Rai Indrasari, M.Kes, Sp. THT-KL (K), FICS;dr. Camelia Herdini, M.Kes, Sp. THT-KL (K), FICS

2016 | Skripsi | S1 PENDIDIKAN DOKTER

Latar belakang: Telah diketahui bahwa inflamasi mempengaruhi progesivitas keganasan. Neutrofil sebagai salah satu sel inflamasi diduga turut berperan dalam menentukan prognosis suatu keganasan. Diperlukan evaluasi lebih lanjut untuk menentukan hubungan antara angka neutrofil dengan stadium klinis pasien KNF di RSUP Dr. Sardjito. Tujuan: Mengetahui hubungan antara angka neutrofil dengan stadium klinis penderita karsinoma nasofarings di RSUP Dr. Sardjito Metode: Rancangan penelitian adalah potong lintang. Data sampel pada penelitian ini diambil dari data rekam medis di RSUP Dr. Sardjito yang terdiagnosis karsinoma nasofarings dan mempunyai data hasil tes laboratorium. Stadium klinis penderita karsinoma nasofarings diklasifikasikan menjadi stadium awal dan stadium lanjut dan angka neutrofil diklasifikasikan menjadi angka neutrofil rendah dan angka neutrofil tinggi. Analisis statistik untuk membuktikan hipotesis menggunakan Fisher’s exact test. Hasil: Sampel penelitian berjumlah 138 penderita karsinoma nasofarings. Tidak terdapat hubungan yang bermakna antara angka neutrofil dengan stadium klinis penderita karsinoma nasofarings di RSUP Dr. Sardjito, dengan nilai p=0,638. Kesimpulan: Tidak terdapat hubungan yang bermakna antara angka neutrofil dengan stadium klinis penderita karsinoma nasofarings di RSUP Dr. Sardjito

Background: It is known that inflammation affects the progression of malignancy. Neutrophils as one of the inflammatory cells may play a role in determining the prognosis in malignancy. Further evaluation is required to determine the association of neutrophil count with clinical stage in nasopharyngeal carcinoma patients at RSUP Dr. Sardjito Purpose: To determine the association of neutrophil count with clinical staging in nasopharyngeal carcinoma at RSUP Dr. Sardjito Methods: The study design was cross-sectional. Sample of this research were taken from medical records of patients which been diagnosed with nasopharyngeal carcinoma and have the data results of laboratory tests. Clinical staging of nasopharyngeal carcinoma were classified into early-stage and advanced stage and neutrophil count were classified into low neutrophil count and high neutrophil count. Statistical analysis to prove the hypothesis were using Fisher's exact test. Result: Study sample were 138 nasopharyngeal carcinoma patients. There was no statistically significant association of neutrofil count with clinical staging in nasopharyngeal carcinoma at RSUP Dr. Sardjito, with p=0,638. Conclusion: There was no association of neutrophil count with clinical staging in nasopharyngeal carcinoma at RSUP Dr. Sardjito

Kata Kunci : Karsinoma nasofarings, angka neutrofil, stadium klinis/Nasopharyngeal carcinoma, neutrophil count, clinical staging