Hubungan Angka Limfosit Dengan Stadium Klinis Penderita Karsinoma Nasofarings di RSUP Dr Sardjito

JESICA ROSALINA, Dr. dr. Sagung Rai Indrasari, M.Kes, Sp.THT-KL(K), FICS; dr. Camelia Herdini, M.Kes, Sp. THT-KL(K), FICS

2016 | Skripsi | S1 PENDIDIKAN DOKTER

Latar Belakang: Banyak faktor yang mempengaruhi peningkatan laju metastasis dan perkembangan suatu tumor. Salah satunya adalah respon inflamasi yang melibatkan banyak agen-agen anti inflamasi yaitu, komponen dari sel darah putih misalnya limfosit, neutrofil, dan monosit. Pada pemeriksaan patologi anatomi dari hasil biopsi pasien karsinoma nasofarings, akan terlihat adanya gambaran infiltrasi sel-sel limfosit yang mengelilingi sel tumor. Tujuan: Mengetahui hubungan angka limfosit dengan stadium klinis penderita karsinoma nasofaring di RSUP Dr. Sardjito. Metode: Rancangan penelitian yang digunakan adalah dengan pendekatan potong-lintang (cross-sectional). Data sampel dalam penelitian ini diambil dari data sekunder berupa rekam medis pasien. Stadium klinis karsinoma nasofarings ditentukan menggunakan klasifikasi TNM menurut AJCC. Hubungan antara kadar limfosit dengan stadium klinis karsinoma nasofarings dianalisis menggunakan chi-square. Hasil: Sampel penelitian berjumlah 138 pasien karsinoma nasofarings. Tidak terdapat hubungan bermakna antara angka limfosit dengan stadium klinis pasien, dengan nilai p=0,580. Kesimpulan: Tidak terdapat hubungan antara angka limfosit dengan stadium klinis penderita karsinoma nasofarings pada pasien penderita karsinoma nasofarings di RSUP Dr. Sardjito.

Background: Many factors affect the increasing rate of metastasis of a tumor. One of them is the inflammatory responses involving many agents of anti-inflammatory such as lymphocytes. On pathological anatomy examination, the results of a biopsy from patient with nasopharyngeal carcinoma, will be seen the image of cells infiltration surrounding the tumor cells. This may indicate the existence of the process and the inflammatory responses in the area. Purpose: To know a relationship between the number of lymphocytes and clinical staging from patient with nasopharyngeal carcinoma in RSUP Dr. Sardjito. Method: The study design was cross-sectional. The sample data in this study was taken from medical records. While the clinical staging of nasopharyngeal carcinoma was determined using AJCC TNM classification. The relationship between the level of the lymphocytes and the clinical staging of nasopharyngeal carcinoma was analyzed using chi-square test. Result: Research samples were 138 patients with nasopharyngeal carcinoma. There was no meaningful relationship between the number of lymphocytes with clinical staging, with the value of p=0,580. Conclusion: There was no relationship between the number of lymphocytes and the clinical staging from patient with nasopharyngeal caracinoma in RSUP Dr. Sardjito.

Kata Kunci : Karsinoma nasofarings, angka limfosit, stadium klinis/Nasopharyngeal carcinoma, number of lymphocytes, clinical staging