Latar Belakang: Gangguan kognitif ringan/Mild Cognitive Impairment (MCI) merupakan salah faktor risiko terjadinya demensia. Demensia berhubungan dengan faktor risiko diabetes melitus. Pada studi prospektif Rotterdam dan Hisayama, serta studi retrospektif Rochester, menunjukan risiko kejadian demensia Alzheimer (AD) meningkat dua kali pada individu dengan DM tipe 2. Mediator inflamasi lipid melalui jalur siklooksigenasi yang diperantarai oleh enzim sPLA, dapat menghubungkan antara gangguan kognitif yang disebabkan oleh kerusakan vaskuler maupun non vaskuler. Berdasarkan teori tersebut, dimungkinkan adanya hubungan antara kadar sPLA2 tipe IIA plasma dengan derajat gangguan kognitif. Tujuan Penelitian: Mengetahui hubungan antara kadar sPLA2 tipe IIA plasma dengan gangguan kognitif. diabetes melitus tipe 2 . Metode dan Cara Penelitian: Disain penelitian potong lintang, dengan subyek penderita DM yang kontrol di poli endokrin RS. Dr. Sardjito, pada bulan Agustus- Desember 2006. Dilakukan penilaian MMSE sebagai perangkat ukur gangguan kognitif dan diperiksa kadar sPLAnya. Hasil Penelitian: Didapat 41 subyek penelitian dengan perbandingan jenis kelamin laki-laki dan perempuan hampir sama (49%:51%), dengan rerata umur 62.82 ± 7.45 tahun, lama DM pada keseluruhan subyek adalah 10.00 ± 5.05 tahun, latar belakang pendidikan subyek dibagi menjadi dua kategori yaitu dasar (pendidikan 9 tahun dari SD – SMP), keduanya mempunyai perbedaan bermakna pada status kognitifnya dengan p=0.029. Berdasar analilisis tak berpasangan didapatkan hubungan antara kadar plasma sPLA2 tipe IIA.gangguan kognitif dengan pada DM tipe 2 Simpulan: Terdapat hubungan antara kadar sPLA2 tipe IIA plasma dengan gangguan kognitif pada penderita DM tipe 2.

Background : Mild cognitive impairment is one of the risk to get Dementia.Dementia connected with the risk factor of diabetes mellitus (DM). At prospective study Rptterdam and Hisamaya, and also the retrospective Rochester study show that the risk of Alzheimer (AD) become two time greater as risk as at person with type 2 DM. Mediator of lipid inflammation through cyclooxygenation way mediated by sPLA enzym, which is a pathogenesis pathway that connecting cognitive impairment due to vascular or non vascular damage. Based on this theory, there is possibility between relationship plasma value sPLA2 type IIA with cognitive impairment at type 2 DM patients. Objective : To find relationship between plasma value of sPLA2 type IIA with cognitive impairment at type 2 DM patients. Methods : Cross sectional study with DM patients who came at endocrine’s clinic Sardjito’s Hospital on August – Desember 2006 as subject. Do mark of Mini Mental Examination State (MMSE) is cognitive impairment’s count instrument and check plasma value of sPLA2 type IIA. Result : There is 41 research’s subject with sex comparement male and female almost same (49% : 51%), age average 62.82 ± 7.45 y.o, take the education background of the subject with two category which is basic education (9 years education from elementary – junior high school) and high school on the same grade or higher (= D1). We found different significancy in both group on cognitive status (p=0.029). By uncouple analysis as basic analysis, there is relationship with cognitive impairment (MMSE value) with plasma value sPLA2 type IIA at type 2 DM patients. Conclution : There’s relationship between plasma value sPLA2 type IIA with cognitive impairment at type 2 DM patients.

Kata Kunci : Diabetes Melitus Tipe 2,Kadar sPLA2 Tipe IIA, Cognitive impairment, sPLA2 type IIA, Type 2 Diabetes Mellitus.