CORRELATION BETWEEN VASCULAR ENDOTHELIAL GROWTH FACTOR-A WITH CLINICOPATHOLOGY PROFILE OF PATIENT WITH COLORECTAL CANCER

M IVAN AULIA SANI, dr. Susanna Hilda Hutajulu, Ph.D Sp.PD, K-HOM; Dewi Kartikawati Paramita, S.Si, M.Si, Ph.D

2016 | Skripsi | S1 PENDIDIKAN DOKTER

Latar belakang: Kanker kolorektal adalah keganasan tersering ke tiga di seluruh dunia. Angiogenesis berperan penting untuk perkembangan kanker kolorektal. Vascular Endothelial Growth Factor-A (VEGF-A) merupakan proangiogenik sitokin yang paling poten. Beberapa penelitian menunjukan bahwa terdapat hubungan yang signifikan antara VEGF-A dengan aspek klinikopatologi. Penelitian tentang hubungan VEGF-A dengan profil klinikopatologi penting untuk dilakukan untuk menambah pemahaman tentang angiogenesis dan karsinogenesis di Indonesia. Tujuan: Untuk mengetahui hubungan ekspresi VEGF-A dengan profil klinikopatologi pasien dengan kanker kolorektal di RSUP Dr. Sardjito, Yogyakarta. Metode: Penelitian ini menggunakan desain cross sectional dan bagian dari peneltian dari Divisi hematologi dan Onkologi Medis, Departemen Penyakit Dalam, RSUP Dr. Sardjito. Data penelitian berasal dari pasien dengan kanker kolorektal yang telah terdiagnosis pada Januari 2007 - Juli 2012 dan profil klinis dan histopatolgi mereka. Data demografi dan klinikopatologi didapat dari rekam medis dan jaringan kolorektal pasien didapat dari arsip patologi. Ekspresi VEGF-A dinilai menggunakan teknik imunohistokimia. Hubungan antara VEGF-A dengan profil klinikopatologi dianalisis menggunakan statistik. Hasil: Dari beberapa parameter, terdapat hubungan yang signifikan antara VEGF-A dengan jenis kelamin laki-laki pasien. Kesimpulan: Terdapat terdapat hubungan yang signifikan antara VEGF-A dengan jenis kelamin laki-laki pasien.

Background: Colorectal cancer is a malignancy included as the third most common cancer worldwide. Angiogenesis plays an important role in the development colorectal cancer. Vascular Endothelial Growth Factor-A (VEGF-A) is the most potent proangiogenic cytokine. Multiple studies suggested that there was a significant correlation between VEGF-A expression with several aspects of clinicopathology. It is important to investigate the correlation between VEGF-A expression with clinicopathology profile of patient with colorectal cancer to enrich understanding about angiogenesis and carcinogenesis in Indonesia. Objective: To investigate the correlation between VEGF-A expression with clinicopathology profile of patient with colorectal cancer in Dr. Sardjito General Hospital, Yogyakarta. Method: The study was cross sectionally designed and was a part of the ongoing study conducted in Division of Hematology and Medical Oncology of Internal Medicine Department, Dr. Sardjito General Hospital. This study included data from colorectal cancer patients who were diagnosed on January 2007 until July 2012 and their clinical and histopathological profile. Demography and clinicopahtological data were obtained from medical record and the corresponding paraffin-embedded tissues were collected from pathology archive. VEGF-A expression was assessed using immunohistochemistry. The correlation were statistically analyzed. Results: Among all parameters, there was a significant correlation between VEGF-A expression with male gender of the patient (p=0.003). Conclusion: In the local colorectal patients, there was a significant correlation between VEGF-A expression with male gender

Kata Kunci : colorectal cancer, VEGF-A, angiogensis