Efek ketorolak 30 mg intravena sebagai preemtive analgesia pada operasi removal implant bedah ortopedi

YANTORO, Awal Tunis, dr. Bambang SS, SpAnK, KIC,MKes,KNA

2009 | Tesis | S2 PPDS 1-Anestesiologi dan Reanimasi

Penelitian ini bertujuan mengetahui efek ketorolak 30 mg IV sebagai preemptive analgesia dalam mengurangi nyeri pasca bedah ortopedi removal implant. Rancangan penelitian ini adalah acak buta berganda (double blind randomized controlled trial / RCT). Subyek penelitian berjumlah 50 pasien, status fisik ASA I-II, usia 18-55 tahun, BMI kurang dari 30, menjalani prosedur pembedahan elektif ortopedi removal implant dengan anestesi umum. Subyek dirandomisasi menjadi 2 kelompok, kelompok A (n=25) mendapat ketorolak 30 mg IV, kelompok B (n=25) mendapat plasebo, 30 menit sebelum incisi. Dilakukan pengamatan skor nyeri di ruang pulih sadar jam ke 1 dilanjutkan di bangsal jam ke 6 dan 12 pasca bedah. Pengukuran dengan Visual Analog Scales (VAS) dan penambahan rescue fentanil sesuai kebutuhan pasien. Analisa data menggunakan chi square test dengan kemaknaan p< 0.05. Hasil penelitian menunjukkan bahwa ada perbedaan bermakna secara statistik rerata skor VAS kelompok A (ketorolak) dan B (plasebo) pada jam ke 1, jam ke 6, jam ke 12 pasca bedah (p=0,001, p=0,005, p=0,003) dan rescue fentanil pada jam ke 1, jam ke 6, jam ke 12 pasca bedah (p=0,01, p=0,02, p=0,018). Hasil penelitian menunjukkan bahwa pemberian ketorolak 30 mg IV mempunyai efek sebagai preemptive analgesia pada operasi bedah ortopedi dengan tindakan removal implant.

The objective of this research was to know and evaluate the ketorolac 30 mg IV effect as preemptive analgesia in orthopaedic surgery removal implant. Methode of this research was double blind randomized controlled trial (RCT). Subject were 50 patients, physical satus ASA I-II, 18-55 years old, BMI <30, who were going to schedule for elective orthopaedic surgery removal implant under general anesthesia. The subject were divided into two groups using randomisation, group A (ketorolac 30 mg IV; n=25), group B (placebo; n=25) received 30 minute before skin incision. Observation pain scale for first hour post operative in the recovery room, 6th and 12th hours at ward. Measurement was using Visual Analog Scales (VAS) and rescue fentanyl as patient need. Data analysis with chi square test with statistically significant p<0,05. The result of study shows there were significant different between two group in mean VAS score at 1st hour (p=0,001), 6th hours (p=0,005), and 12th hours (p=0,003) post operative and rescue fentanyl at 1st hour (p=0,01), 6th hours (p=0,02), and 12th hours (p=0,018). The conclusion of this research, ketorolac 30 mg IV have effect as preemptive analgesia in orthopaedic surgery removal implant.

Kata Kunci : Preemptive analgesia,Ketorolak,VAS,preemptive analgesia, ketorolac, VAS