Hasil guna pengobatan Betahistin Dihidroklorid dibanding flunarisin pada vertigo perifer

MUZAYYIN, Ahmad, Dr.dr. Sri Sutarni, Sp.S(K)

2006 | Tesis | S2 Ilmu Kedokteran Klinik

Pusing adalah keluhan utama yang dapat disebabkan oleh simtom berbagai macam penyakit. Menurut National Institutes of Health National Institute of Deafness and Other Communication Disorders (NIDCD), sekitar 40% orang Amerika memerlukan pelayanan medis untuk keluhan pusing dan dilaporkan sejumlah 50% dari semua kematian pada lanjut usia. Penelitian pasien dengan pusing atau dizzy dari 12 klinik menunjukkan bahwa 50% diagnosis pasien pada pelayanan medis dasar mengalami vestibulopati perifer seperti benign positional vertigo, vestibular neuritis, atau Meniere’s disease. Penatalaksanaan pasien-pasien dengan vertigo perifer sering kontroversi karena patofisiologi vertigo yang belum jelas. Beberapa obat ditemukan memiliki aktivitas antivertigo. Terapi yang ideal harus mempunyai onset cepat dan efektif serta efek samping minimal. Betahistin menyerupai histamin untuk terapi gangguan vaskuler dan vasomotor, dipakai untuk pengobatan vertigo, motion sickness, dan gangguan vestibuler sentral atau perifer. Tujuan penelitian ini adalah mengetahui hasil guna betahistin dibanding flunarisin untuk pengobatan vertigo perifer. Metode penelitian digunakan rancangan acak terkendali buta ganda. Subyek penelitian adalah semua pasien dengan vertigo perifer yang berobat di unit rawat jalan poliklinik dan rawat inap di bagian Penyakit Saraf RS Dr. Sardjito Yogyakarta. Pengambilan sampel menggunakan permuted block. Untuk mengetahui perbedaan efektifitas antara betahistin dihidroklorid dan flunarisin pada penderita vertigo perifer, dengan perbaikan derajat keluhan vertigo digunakan skala Dizziness Handicap Inventory (DHI).

Dizziness is a common chief complaint and symptom of multiple diseases. According to the National Institutes of Health National Institute of Deafness and Other Communication Disorders (NIDCD), approximately 40% of all Americans need medical attention for dizziness in their lives. NIDCD also reports that 50% of deaths in the elderly. Study of patients with dizziness from 12 clinicals showed that 50% of patients in primary care had peripheral vestibulopathy such as benign positional vertigo, vestibular neuritis or Meniere’s disease. The management of patients with peripheral vertigo is controversial, cause the pathophysiology is uncertain. Many pharmacological agents have been found an antivertiginous activity. An ideal therapy should be rapid in onset and effective, and lack debilitating side effects. Betahistine, a histamine-like substance was introduced as an active drug in the treatment of vascular and vasomotor disorders. Later it was used to treat vertigo, motion sickness and various vestibular disorders of central and peripheral origin. The objectives of this study is to elicit the effectivity betahistine comparing flunarizine on the peripheral vertigo treatment. The design of this study was double blind randomized control trial. Subjects were patients with peripheral vertigo who cured on outpatient unit and inpatient unit of neurology department of Sardjito general hospital Yogyakarta. The sampling subjects used permuted block. To be used Dizziness Handicap Inventory (DHI) scale to measure the effectivity between betahistine dihydrochloride and flunarizine on peripheral vertigo patients.

Kata Kunci : Vertigo Perifer,Flunarisin dan Betahistin Dihidroklorid, Betahistine dihydrochlorid – Flunarizine- Peripheral Vertigo- DHI