FABRIKASI MEMBRAN NANOFIBER POLYSULFONE (PSF)/POLYETHYLENE OXIDE (PEO) DAN POTENSINYA SEBAGAI BIOMATERIAL

RAHMADIAN MUHENDAR, Dr. Eng. Ahmad Kusumaatmaja, S.Si., M.Sc

2022 | Skripsi | S1 FISIKA

Membran nanofiber memiliki potensi untuk diaplikasikan dalam berbagai bidang khususnya bidang biomedis. Membran nanofiber Polysulfone (PSF) dan Polyethylene Oxide (PEO) difabrikasi dengan metode electrospinning untuk aplikasi dalam bidang biomedis. Membran nanofiber PSF/PEO dibuat dengan larutan PSF konsentrasi 12 wt% dan larutan PEO konsentrasi 4 wt%. Membran PSF/PEO dikarakterisasi dengan Scanning Electron Microscopy (SEM), dilakukan uji sudut kontak dengan metode sessile drop untuk mengetahui sifat keterbasahan permukaan membran, dan uji swelling dengan larutan Phophate Buffered Saline (PBS). Morfologi optimal terdapat pada membran nanofiber PSF/PEO 25/75 diperoleh diameter rata-rata (277± 2) nm. Uji sudut kontak yang diperoleh menunjukkan semakin besar rasio volume PEO maka semakin kecil sudut kontak membran. Hasil swelling optimal terdapat pada membran PSF/PEO 75/25 berdasarkan ketahanannya terhadap swelling dan didapatkan nilai derajat swelling (4,3 ± 0,4) x 10^2 %. Berdasarkan penelitian ini diperlukan pengujian lebih lanjut terkait uji in vitro MTT assay untuk mendapatkan hasil yang lebih komprehensif terkait bikompatibilitas material tersebut.

Nanofiber membranes have the potential to be applied in various fields, especially the biomedical field. Polysulfone (PSF) and Polyethylene Oxide (PEO) nanofiber membranes were fabricated using the electrospinning method for applications in the biomedical field. The PSF/PEO nanofiber membrane was made using a solution of PSF with a concentration of 12 wt% and a solution of PEO with a concentration of 4 wt% using the electrospinning method. The PSF/PEO membrane was characterized using a Scanning Electron Microscopy (SEM), a contact angle test was performed using the sessile drop method, and a swelling test using Phophate Buffered Saline PBS solution. The optimal morphology is found in the PSF/PEO 25/75 nanofiber membrane with an average diameter (277 ± 2) nm. The contact angle test obtained shows that the greater the PEO volume ratio, the smaller the membrane contact angle. The optimal swelling results are found in the PSF / PEO 75/25 membrane based on its resistance to swelling and obtained the degree of swelling (4.3 ± 0.4) x 10^2%. Based on this research, further testing is needed related to the in vitro test of MTT assay to obtain more comprehensive results related to the bicompatibility of the material.

Kata Kunci : Nanofiber, Elektrospinning, Polysulfone (PSF), Polyethylene Oxide (PEO), Scanning Electron Microscopy, Sessile Drop, Swelling