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Pola Ekspresi Interleukin-8 Berdasar Topografi Endoskopi Peradangan Mukosa Gastroduodenal yang Terinfeksi Helicobacter pylori

RUDYANTO DWI AGUSTOMO, Prof. dr. Siti Nurdjanah, M.Kes., SpPD-KGEH.; dr. Neneng Ratnasari, SpPD-KGEH.

2015 | Tesis-Spesialis | SP Ilmu Penyakit Dalam

Latar belakang: Prevalensi infeksi Helicobacter pylori di negara berkembang 80%, di negara maju < 40%. Infeksi Helicobacter pylori menyebabkan pelepasan interleukin-8 dan rekrutmen netrofil, hipergastrinemia pada gastritis predominan antrum, gastritis atropi dan kanker pada gastritis predominan korpus. Belum ada penelitian perbedaan ekspresi IL-8 berdasarkan topografi endoskopi peradangan mukosa gastroduodenal yang terinfeksi Helicobacter pylori di RSUP dr Sardjito. Tujuan Penelitian: Mengetahui perbedaan ekspresi interleukin-8 berdasarkan topografi endoskopi peradangan mukosa gastroduodenal yang terinfeksi Helicobacter pylori. Metode: Penelitian ini menggunakan desain potong lintang.Dilakukan pemeriksaan ekspresi interleukin-8 pada sisa sampel biopsi Helicobacter pylori (+) bulan Januari 2009 hingga Maret 2014. Topografi peradangan mukosa gastroduodenal diperoleh melalui laporan endoskopi.Data numerik-kategorik 2 kelompok tidak berpasangan, distribusi tidak normal, menggunakan uji MannWhitney, lebih dari 2 kelompok menggunakan uji Kruskal wallis. Kemaknaan p < 0,05 dianggap signifikan. Data diolah menggunakan program SPSS versi 16.0 Hasil: Didapatkan 51 sampel biopsi yang terdiri dari 20 (39.2%) gastritis predominan antrum, 8 (15.7%) gastritis predominan korpus, 20 (39.2%)pangastritis, dan 3 (5.9%) duodenitis. Ekspresi interleukin-8 pada gastritis predominan antrum sebesar 82 (19-95)%, gastritis predominan korpus 70+-1.7%, pangastritis 82.5 (19-96) %, dan duodenitis 67.8+-1.9 %. Dilakukan uji komparasi dengan uji Kruskal Wallis didapatkan p=0.628. Simpulan: Perbedaan ekspresi interleukin-8 berdasarkan topografi endoskopi peradangan mukosa gastroduodenal yang terinfeksi Helicobacter pylori tidak bermakna secara statistik.

Background: The prevalence of Helicobacter pylori infection in developing countries 80%, in developed countries <40%. Helicobacter pylori infection causing the release of interleukin-8 and recruitment of neutrophils, hipergastrinemia in antrum predominant gastritis, atrophic gastritis, and cancers of the corpus predominant gastritis. There has been no research on differences in the expression of IL-8 based on topography of endoscopic of gastroduodenal mucosal inflammation infected Helicobacter pylori in the Hospital Dr. Sardjito Objective: Knowing the differences in the expression of IL-8 based on topography of endoscopic of gastroduodenal mucosal inflammation infected Helicobacter pylori Methods: This study used a cross-sectional design. Examined the expression of interleukin-8 of the biopsy sample Helicobacter pylori (+) from January 2009 to December 2012. The topography of gastroduodenal mucosal inflammation obtained through endoscopy report. Analysis of categorical and numerical data of 2 groups, unpaired, abnormal distribution using Mann-Whitney test, more than 2 groups using Kruskal Wallis test. P value < 0,05 was considered significant. The data were processed using SPSS version 16.0 Results: There were 51 biopsy samples consisted of 20 (39.2 %) predominantly antral gastritis, 8 (15.7 %) corpus predominant gastritis, 20 (39.2 %)pangastritis , and 3 (5.9 %) duodenitis. Expression of interleukin - 8 on the predominant antral gastritis by 82 (19-95) % , predominantly corpus gastritis 70 +- 1.7 % , 82.5 pangastritis (19-96) % , and 67.8 +- 1.9 % duodenitis. Comparison test conducted with Kruskal Wallis test was obtained p = 0.628 . Conclusion: Differences in the expression of interleukin-8 by topography endoscopy of gastroduodenal mucosal inflammation infected by Helicobacter pylori were no statistically significant.

Kata Kunci : Helicobacter pylori, interleukin-8, topography of gastroduodenal mucosal inflammation


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